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• W2899668873 abstract "Gonadotrophin‐releasing hormone (Gn RH ) neurone function is dependent upon gonadal steroid hormone feedback, which is communicated in large part through an afferent neuronal network. The classical neurotransmitters GABA and glutamate are important regulators of Gn RH neurone activity and are implicated in mediating feedback signals. In the present study, we aimed to determine whether GABA ergic or glutamatergic input to Gn RH neurones differs between males and females and/or exhibits morphological plasticity in response to steroid hormone feedback in females. Tissue collected from Gn RH ‐green fluorescent protein ( GFP ) male and female mice in dioestrus underwent immunofluorescence labelling of GFP and either the vesicular GABA transporter ( VGAT ) or the vesicular glutamate transporter 2 ( VGLUT 2). No differences in the densities or absolute numbers of VGAT ‐immunoreactive (‐IR) or VGLUT 2‐IR puncta apposed to Gn RH neurones were identified between males and females. The most significant input from either neurotransmitter was to the proximal dendritic region and 80% of VGAT ‐IR puncta apposed to Gn RH neurones co‐localised with synaptophysin. Putative inputs were also assessed in ovariectomised ( OVX ) female mice treated with negative ( OVX +E) or positive ( OVX +E+E) feedback levels of oestrogen, and OVX +E+E mice were killed during the expected Gn RH /luteinising hormone surge. No differences in VGLUT 2‐IR contacts to Gn RH neurones were identified between animals under the negative‐feedback influence of oestrogen ( OVX +E) or the positive influence of oestrogen ( OVX +E+E), regardless of cF os activation status. By contrast, a significant elevation in putative GABA ergic inputs to Gn RH neurones at the time of the preovulatory surge was found in the cF os‐negative subset of Gn RH neurones, both at the level of the soma and at the proximal dendrite. Taken together, these data suggest that, although GABA ergic and glutamatergic innervation of Gn RH neurones is not sexually differentiated, cyclic fluctuations in steroid hormone feedback over the female oestrous cycle result in plastic changes in GABA ergic inputs to a subpopulation of Gn RH neurones." @default.
• W2899668873 created "2018-11-16" @default.
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• W2899668873 date "2018-11-29" @default.
• W2899668873 modified "2023-10-17" @default.
• W2899668873 title "Mapping <scp>GABA</scp> and glutamate inputs to gonadotrophin‐releasing hormone neurones in male and female mice" @default.
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• W2899668873 doi "https://doi.org/10.1111/jne.12657" @default.
• W2899668873 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30415474" @default.
• W2899668873 hasPublicationYear "2018" @default.
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