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- W2899672214 abstract "Several lines of investigations converge upon aberrant synaptic plasticity as a potential pathophysiological characteristic of schizophrenia. In vivo experiments using neuromodulatory perturbation techniques like Transcranial Magnetic and Direct Current Stimulation (TMS & tDCS) have been increasingly used to measure ‘motor cortical plasticity’ in schizophrenia. A systematic quantification of cortical plasticity and its moderators in schizophrenia is however lacking. The PubMed/MEDLINE database was searched for studies up to December 31st, 2017 that examined case-control experiments comparing neuromodulation following single-session of TMS or tDCS. The primary outcome was the standardized mean difference for differential changes in motor evoked potential (MEP) amplitudes measured with single-pulse TMS (MEP Δ) between patients and healthy subjects following TMS or tDCS. After examining heterogeneity, meta-analyses were performed using fixed effects models. A total of 16 datasets comparing cortical plasticity (MEP Δ) between 189 schizophrenia patients and 187 healthy controls were included in the meta-analysis. Patients demonstrated diminished MEP Δ with effect sizes (Cohen's d) ranging from 0.66 (LTP-like plasticity) to 0.68 (LTD-like plasticity). Heterosynaptic plasticity studies demonstrated a greater effect size (0.79) compared to homosynaptic plasticity studies (0.62), though not significant (P = 0.43). Clinical, perturbation protocol- and measurement-related factors, and study quality did not significantly moderate the aberrant plasticity demonstrated in schizophrenia. Schizophrenia patients demonstrate diminished LTP- and LTD-like motor cortical plasticity, which is not influenced by the various clinical and experimental protocol related confounders. These consistent findings should encourage the use of perturbation-based biomarkers to characterize illness trajectories and treatment response." @default.
- W2899672214 created "2018-11-16" @default.
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- W2899672214 date "2019-05-01" @default.
- W2899672214 modified "2023-10-16" @default.
- W2899672214 title "Motor cortical plasticity in schizophrenia: A meta-analysis of Transcranial Magnetic Stimulation – Electromyography studies" @default.
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- W2899672214 cites W1913234983 @default.
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- W2899672214 cites W1985241009 @default.
- W2899672214 cites W1989850420 @default.
- W2899672214 cites W1991516231 @default.
- W2899672214 cites W1994642099 @default.
- W2899672214 cites W1995729049 @default.
- W2899672214 cites W2000822335 @default.
- W2899672214 cites W2003930741 @default.
- W2899672214 cites W2018422842 @default.
- W2899672214 cites W2021327271 @default.
- W2899672214 cites W2022047741 @default.
- W2899672214 cites W2028921525 @default.
- W2899672214 cites W2032210947 @default.
- W2899672214 cites W2037097587 @default.
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- W2899672214 cites W2588283669 @default.
- W2899672214 cites W2598713899 @default.
- W2899672214 cites W2617903284 @default.
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- W2899672214 doi "https://doi.org/10.1016/j.schres.2018.10.027" @default.
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