Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899673614> ?p ?o ?g. }
- W2899673614 endingPage "439" @default.
- W2899673614 startingPage "439" @default.
- W2899673614 abstract "For enhanced intracellular accumulation of 6-mercaptopurine (6-MP) in leukemia, a folate receptor-targeted and glutathione (GSH)-responsive polymeric prodrug nanoparticle was made. The nanoparticles were prepared by conjugating 6-MP to carboxymethyl chitosan via a GSH-sensitive carbonyl vinyl sulfide linkage, ultrasonic self-assembly and surface decoration with folate. The TEM graphs shows that the as-synthesized nanoparticles are spherical with a particle size of 170~220 nm. In vitro drug release of nanoparticles demonstrated acceptable stability in PBS containing 20 μM GSH at pH 7.4. However, the cumulative drug release rate of the samples containing 20 mM and 10 mM GSH medium reached 78.9% and 64.8%, respectively, in pH 5.0 at 20 h. This indicated that this nano-sized system is highly sensitive to GSH. The inhibition ratio of folate-modified nanoparticles compared to unmodified nanoparticles was higher in cancer cells (human promyelocytic leukemia cells, HL-60) while their cytotoxicity was lower in normal cells (mouse fibroblast cell lines, L929). Furthermore, in vitro cancer cell incubation studies confirmed that folate-modified nanoparticles therapeutics were significantly more effective than unmodified nanoparticles therapeutics. Our results suggest that folate receptor-targeting and GSH-stimulation can significantly elevate tumour intracellular drug release. Therefore, folate-modified nanoparticles containing chemoradiotherapy is a potential treatment for leukemia therapy." @default.
- W2899673614 created "2018-11-16" @default.
- W2899673614 creator A5002654386 @default.
- W2899673614 creator A5005355173 @default.
- W2899673614 creator A5010395010 @default.
- W2899673614 creator A5013134577 @default.
- W2899673614 creator A5041683758 @default.
- W2899673614 creator A5045311925 @default.
- W2899673614 creator A5065487257 @default.
- W2899673614 creator A5065701806 @default.
- W2899673614 creator A5075151504 @default.
- W2899673614 creator A5077607026 @default.
- W2899673614 creator A5078983941 @default.
- W2899673614 date "2018-11-08" @default.
- W2899673614 modified "2023-10-05" @default.
- W2899673614 title "Folate Receptor-Targeted and GSH-Responsive Carboxymethyl Chitosan Nanoparticles Containing Covalently Entrapped 6-Mercaptopurine for Enhanced Intracellular Drug Delivery in Leukemia" @default.
- W2899673614 cites W1966090623 @default.
- W2899673614 cites W1972728021 @default.
- W2899673614 cites W1989979542 @default.
- W2899673614 cites W2008644522 @default.
- W2899673614 cites W2009697738 @default.
- W2899673614 cites W2016543419 @default.
- W2899673614 cites W2017159766 @default.
- W2899673614 cites W2019207861 @default.
- W2899673614 cites W2025345565 @default.
- W2899673614 cites W2036828387 @default.
- W2899673614 cites W2054394029 @default.
- W2899673614 cites W2063859653 @default.
- W2899673614 cites W2066734110 @default.
- W2899673614 cites W2067737842 @default.
- W2899673614 cites W2067848116 @default.
- W2899673614 cites W2073447604 @default.
- W2899673614 cites W2074741766 @default.
- W2899673614 cites W2089374836 @default.
- W2899673614 cites W2092435825 @default.
- W2899673614 cites W2105021536 @default.
- W2899673614 cites W2342589567 @default.
- W2899673614 cites W2428197920 @default.
- W2899673614 cites W2482918599 @default.
- W2899673614 cites W2521218416 @default.
- W2899673614 cites W2531742571 @default.
- W2899673614 cites W2564872481 @default.
- W2899673614 cites W2577306963 @default.
- W2899673614 cites W2601714070 @default.
- W2899673614 cites W2602677682 @default.
- W2899673614 cites W2727421336 @default.
- W2899673614 cites W2730071659 @default.
- W2899673614 cites W2745043218 @default.
- W2899673614 cites W2750142910 @default.
- W2899673614 cites W2765087004 @default.
- W2899673614 cites W2767263496 @default.
- W2899673614 cites W2773219502 @default.
- W2899673614 cites W2773313167 @default.
- W2899673614 cites W4239405270 @default.
- W2899673614 doi "https://doi.org/10.3390/md16110439" @default.
- W2899673614 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6266736" @default.
- W2899673614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30413077" @default.
- W2899673614 hasPublicationYear "2018" @default.
- W2899673614 type Work @default.
- W2899673614 sameAs 2899673614 @default.
- W2899673614 citedByCount "91" @default.
- W2899673614 countsByYear W28996736142019 @default.
- W2899673614 countsByYear W28996736142020 @default.
- W2899673614 countsByYear W28996736142021 @default.
- W2899673614 countsByYear W28996736142022 @default.
- W2899673614 countsByYear W28996736142023 @default.
- W2899673614 crossrefType "journal-article" @default.
- W2899673614 hasAuthorship W2899673614A5002654386 @default.
- W2899673614 hasAuthorship W2899673614A5005355173 @default.
- W2899673614 hasAuthorship W2899673614A5010395010 @default.
- W2899673614 hasAuthorship W2899673614A5013134577 @default.
- W2899673614 hasAuthorship W2899673614A5041683758 @default.
- W2899673614 hasAuthorship W2899673614A5045311925 @default.
- W2899673614 hasAuthorship W2899673614A5065487257 @default.
- W2899673614 hasAuthorship W2899673614A5065701806 @default.
- W2899673614 hasAuthorship W2899673614A5075151504 @default.
- W2899673614 hasAuthorship W2899673614A5077607026 @default.
- W2899673614 hasAuthorship W2899673614A5078983941 @default.
- W2899673614 hasBestOaLocation W28996736141 @default.
- W2899673614 hasConcept C109316439 @default.
- W2899673614 hasConcept C121608353 @default.
- W2899673614 hasConcept C12554922 @default.
- W2899673614 hasConcept C126511603 @default.
- W2899673614 hasConcept C178790620 @default.
- W2899673614 hasConcept C181199279 @default.
- W2899673614 hasConcept C185592680 @default.
- W2899673614 hasConcept C202751555 @default.
- W2899673614 hasConcept C2779820397 @default.
- W2899673614 hasConcept C2780306303 @default.
- W2899673614 hasConcept C538909803 @default.
- W2899673614 hasConcept C54355233 @default.
- W2899673614 hasConcept C55493867 @default.
- W2899673614 hasConcept C79879829 @default.
- W2899673614 hasConcept C86803240 @default.
- W2899673614 hasConcept C96232424 @default.
- W2899673614 hasConcept C98274493 @default.
- W2899673614 hasConceptScore W2899673614C109316439 @default.
- W2899673614 hasConceptScore W2899673614C121608353 @default.