Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899683708> ?p ?o ?g. }
- W2899683708 endingPage "60.e1" @default.
- W2899683708 startingPage "55" @default.
- W2899683708 abstract "Objectives To evaluate if obesity is associated with increased angiotensin II (Ang II) and decreased angiotensin-(1-7) or Ang-(1-7) in the circulation and urine among adolescents born prematurely. Study design In a cross-sectional analysis of 175 14-year-olds born preterm with very low birth weight, we quantified plasma and urinary Ang II and Ang-(1-7) and compared their levels between subjects with overweight/obesity (body mass index ≥85th percentile, n = 61) and those with body mass index <85th percentile (n = 114) using generalized linear models, adjusted for race and antenatal corticosteroid exposure. Results Overweight/obesity was associated with higher systolic blood pressure and a greater proportion with high blood pressure. After adjustment for confounders, overweight/obesity was associated with an elevated ratio of plasma Ang II to Ang-(1-7) (β: 0.57, 95% CI 0.23-0.91) and higher Ang II (β: 0.21 pmol/L, 95% CI 0.03-0.39) but lower Ang-(1-7) (β: -0.37 pmol/L, 95% CI −0.7 to −0.04). Overweight/obesity was associated with a higher ratio of urinary Ang II to Ang-(1-7) (β: 0.21, 95% CI −0.02 to 0.44), an effect that approached statistical significance. Conclusions Among preterm-born adolescents, overweight/obesity was associated with increased Ang II but reduced Ang-(1-7) in the circulation and the kidney as well as higher blood pressure. Obesity may compound the increased risk of hypertension and cardiovascular disease in individuals born prematurely by further augmenting the prematurity-associated imbalance in the renin-angiotensin system. To evaluate if obesity is associated with increased angiotensin II (Ang II) and decreased angiotensin-(1-7) or Ang-(1-7) in the circulation and urine among adolescents born prematurely. In a cross-sectional analysis of 175 14-year-olds born preterm with very low birth weight, we quantified plasma and urinary Ang II and Ang-(1-7) and compared their levels between subjects with overweight/obesity (body mass index ≥85th percentile, n = 61) and those with body mass index <85th percentile (n = 114) using generalized linear models, adjusted for race and antenatal corticosteroid exposure. Overweight/obesity was associated with higher systolic blood pressure and a greater proportion with high blood pressure. After adjustment for confounders, overweight/obesity was associated with an elevated ratio of plasma Ang II to Ang-(1-7) (β: 0.57, 95% CI 0.23-0.91) and higher Ang II (β: 0.21 pmol/L, 95% CI 0.03-0.39) but lower Ang-(1-7) (β: -0.37 pmol/L, 95% CI −0.7 to −0.04). Overweight/obesity was associated with a higher ratio of urinary Ang II to Ang-(1-7) (β: 0.21, 95% CI −0.02 to 0.44), an effect that approached statistical significance. Among preterm-born adolescents, overweight/obesity was associated with increased Ang II but reduced Ang-(1-7) in the circulation and the kidney as well as higher blood pressure. Obesity may compound the increased risk of hypertension and cardiovascular disease in individuals born prematurely by further augmenting the prematurity-associated imbalance in the renin-angiotensin system." @default.
- W2899683708 created "2018-11-16" @default.
- W2899683708 creator A5024347949 @default.
- W2899683708 creator A5033200830 @default.
- W2899683708 creator A5034603627 @default.
- W2899683708 creator A5049798703 @default.
- W2899683708 creator A5051899651 @default.
- W2899683708 creator A5054558783 @default.
- W2899683708 creator A5072715305 @default.
- W2899683708 creator A5079702726 @default.
- W2899683708 date "2019-02-01" @default.
- W2899683708 modified "2023-10-18" @default.
- W2899683708 title "Obesity is Associated with Higher Blood Pressure and Higher Levels of Angiotensin II but Lower Angiotensin-(1-7) in Adolescents Born Preterm" @default.
- W2899683708 cites W1579360182 @default.
- W2899683708 cites W2009448766 @default.
- W2899683708 cites W2010266704 @default.
- W2899683708 cites W2018404843 @default.
- W2899683708 cites W2019968372 @default.
- W2899683708 cites W2039654936 @default.
- W2899683708 cites W2048185335 @default.
- W2899683708 cites W2081412553 @default.
- W2899683708 cites W2086781387 @default.
- W2899683708 cites W2089198100 @default.
- W2899683708 cites W2089455848 @default.
- W2899683708 cites W2097090923 @default.
- W2899683708 cites W2117440871 @default.
- W2899683708 cites W2122025671 @default.
- W2899683708 cites W2131451413 @default.
- W2899683708 cites W2137072925 @default.
- W2899683708 cites W2139857937 @default.
- W2899683708 cites W2149062689 @default.
- W2899683708 cites W2149307147 @default.
- W2899683708 cites W2157132733 @default.
- W2899683708 cites W2165700203 @default.
- W2899683708 cites W2279350596 @default.
- W2899683708 cites W2320689286 @default.
- W2899683708 cites W2427572602 @default.
- W2899683708 cites W2518957407 @default.
- W2899683708 cites W2607262074 @default.
- W2899683708 cites W2620501585 @default.
- W2899683708 cites W2803147016 @default.
- W2899683708 cites W4300336248 @default.
- W2899683708 doi "https://doi.org/10.1016/j.jpeds.2018.09.058" @default.
- W2899683708 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6561332" @default.
- W2899683708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30404738" @default.
- W2899683708 hasPublicationYear "2019" @default.
- W2899683708 type Work @default.
- W2899683708 sameAs 2899683708 @default.
- W2899683708 citedByCount "33" @default.
- W2899683708 countsByYear W28996837082019 @default.
- W2899683708 countsByYear W28996837082020 @default.
- W2899683708 countsByYear W28996837082021 @default.
- W2899683708 countsByYear W28996837082022 @default.
- W2899683708 countsByYear W28996837082023 @default.
- W2899683708 crossrefType "journal-article" @default.
- W2899683708 hasAuthorship W2899683708A5024347949 @default.
- W2899683708 hasAuthorship W2899683708A5033200830 @default.
- W2899683708 hasAuthorship W2899683708A5034603627 @default.
- W2899683708 hasAuthorship W2899683708A5049798703 @default.
- W2899683708 hasAuthorship W2899683708A5051899651 @default.
- W2899683708 hasAuthorship W2899683708A5054558783 @default.
- W2899683708 hasAuthorship W2899683708A5072715305 @default.
- W2899683708 hasAuthorship W2899683708A5079702726 @default.
- W2899683708 hasBestOaLocation W28996837082 @default.
- W2899683708 hasConcept C126322002 @default.
- W2899683708 hasConcept C134018914 @default.
- W2899683708 hasConcept C2780221984 @default.
- W2899683708 hasConcept C2780586474 @default.
- W2899683708 hasConcept C2908929049 @default.
- W2899683708 hasConcept C511355011 @default.
- W2899683708 hasConcept C71924100 @default.
- W2899683708 hasConcept C77411442 @default.
- W2899683708 hasConcept C84393581 @default.
- W2899683708 hasConceptScore W2899683708C126322002 @default.
- W2899683708 hasConceptScore W2899683708C134018914 @default.
- W2899683708 hasConceptScore W2899683708C2780221984 @default.
- W2899683708 hasConceptScore W2899683708C2780586474 @default.
- W2899683708 hasConceptScore W2899683708C2908929049 @default.
- W2899683708 hasConceptScore W2899683708C511355011 @default.
- W2899683708 hasConceptScore W2899683708C71924100 @default.
- W2899683708 hasConceptScore W2899683708C77411442 @default.
- W2899683708 hasConceptScore W2899683708C84393581 @default.
- W2899683708 hasFunder F4320306230 @default.
- W2899683708 hasFunder F4320332689 @default.
- W2899683708 hasFunder F4320337611 @default.
- W2899683708 hasLocation W28996837081 @default.
- W2899683708 hasLocation W28996837082 @default.
- W2899683708 hasLocation W28996837083 @default.
- W2899683708 hasLocation W28996837084 @default.
- W2899683708 hasOpenAccess W2899683708 @default.
- W2899683708 hasPrimaryLocation W28996837081 @default.
- W2899683708 hasRelatedWork W1866091461 @default.
- W2899683708 hasRelatedWork W2047277250 @default.
- W2899683708 hasRelatedWork W2069654038 @default.
- W2899683708 hasRelatedWork W2363570094 @default.
- W2899683708 hasRelatedWork W2403825624 @default.
- W2899683708 hasRelatedWork W2625095604 @default.
- W2899683708 hasRelatedWork W2777447650 @default.