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- W2899684830 abstract "Aim: The overexpression of miRNA-21 correlates with the cisplatin (CIS) resistance in the ovarian cancers. Methods: AS1411 antinucleolin aptamer-decorated PEGylated poly(lactic-co-glycolic acid) nanoparticles containing CIS (Ap–CIS–NPs) and anti-miR-21 (Ap-anti-miR-21-NPs) were prepared, physicochemically investigated and their cancer-targeting ability was confirmed. CIS-resistant A2780 cells (A2780 R) were infected with anti-miR-21 using Ap-anti-miR-21-NPs to decrease the drug resistance and sensitize the cells to CIS. Afterward, miR-21-inhibited cells were exposed to the Ap–CIS–NPs. Results: Ap-anti-miR-21-NPs could infect the A2780 R cells mainly through nucleolin-mediated endocytosis and inhibit the endogenous miR-21. Targeted delivery of CIS using Ap–CIS–NPs into the miR-21-inhibited cells caused an enhanced mortality. Conclusion: The targeted delivery of chemotherapeutics to the oncomiR-inhibited cells may find a robust application in cancer chemo/gene therapy." @default.
- W2899684830 created "2018-11-16" @default.
- W2899684830 creator A5003333224 @default.
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- W2899684830 date "2018-11-01" @default.
- W2899684830 modified "2023-09-30" @default.
- W2899684830 title "AS1411 aptamer-decorated cisplatin-loaded poly(lactic-<i>co</i>-glycolic acid) nanoparticles for targeted therapy of miR-21-inhibited ovarian cancer cells" @default.
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- W2899684830 doi "https://doi.org/10.2217/nnm-2018-0205" @default.
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- W2899684830 hasPublicationYear "2018" @default.
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