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• W2899687428 abstract "VRC01 broadly neutralizing antibodies (bnAbs) target the CD4-binding site (CD4BS) of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein (Env). Unlike mature antibodies, corresponding VRC01 germline precursors poorly bind to Env. Immunogen design has mostly relied on glycan removal from trimeric Env constructs and has had limited success in eliciting mature VRC01 bnAbs. To better understand elicitation of such bnAbs, we characterized the inferred germline precursor of VRC01 in complex with a modified trimeric 426c Env by cryo-electron microscopy and a 426c gp120 core by X-ray crystallography, biolayer interferometry, immunoprecipitation, and glycoproteomics. Our results show VRC01 germline antibodies interacted with a wild-type 426c core lacking variable loops 1–3 in the presence and absence of a glycan at position Asn276, with the latter form binding with higher affinity than the former. Interactions in the presence of an Asn276 oligosaccharide could be enhanced upon carbohydrate shortening, which should be considered for immunogen design." @default.
• W2899687428 created "2018-11-16" @default.
• W2899687428 creator A5002836913 @default.
• W2899687428 creator A5006919442 @default.
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• W2899687428 creator A5039670611 @default.
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• W2899687428 creator A5050510032 @default.
• W2899687428 creator A5076958095 @default.
• W2899687428 creator A5085406779 @default.
• W2899687428 date "2018-11-07" @default.
• W2899687428 modified "2023-10-16" @default.
• W2899687428 title "Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core" @default.
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