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- W2899687620 abstract "New strategies for HIV treatment are being investigated to reduce drug-exposure, toxicities, and costs. Dolutegravir (DTG) 50 mg/rilpivirine (RPV) 25 mg was approved in November 2017 by FDA and in May 2018 by the European Medicines Agency (EMA). It is indicated as a complete regimen for HIV-1 infected adults with undetectable plasmatic HIV-RNA for at least 6 months on their current HIV treatment combination. Its approval was based on the data of two randomized, multicenter, non-inferiority trials (SWORD-1 and SWORD-2). Areas covered: We reviewed data from literature about DTG and RPV. We mainly focused on the efficacy and on the safety of this new dual therapy. Its impact on renal function, its bone and cardiovascular profile, its reservoir penetration and its role on inflammation were also evaluated. Expert commentary: Dual therapies may be an attractive alternative to standard triple regimens in terms of tolerability and simplicity. Long-term efficacy of DTG and RPV dual regimen need to be confirmed, where only the extensive use of this new treatment and a longer follow-up will give us the answers." @default.
- W2899687620 created "2018-11-16" @default.
- W2899687620 creator A5033592492 @default.
- W2899687620 creator A5033772759 @default.
- W2899687620 creator A5083236873 @default.
- W2899687620 creator A5088361957 @default.
- W2899687620 date "2018-11-14" @default.
- W2899687620 modified "2023-09-23" @default.
- W2899687620 title "Dolutegravir-rilpivirine: first 2-drug regimen for HIV-positive adults" @default.
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- W2899687620 doi "https://doi.org/10.1080/14787210.2018.1544491" @default.
- W2899687620 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30392419" @default.
- W2899687620 hasPublicationYear "2018" @default.
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