Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899687941> ?p ?o ?g. }
- W2899687941 abstract "Extrahepatic transplantation of islets of Langerhans could aid in better survival of islets after transplantation. When islets are transfused into the liver 60-70% of them are lost immediately after transplantation. An important factor for a successful extrahepatic transplantation is a well-vascularized tissue surrounding the implant. There are many strategies known for enhancing vessel formation such as adding cells with endothelial potential, the combination with angiogenic factors and / or applying surface topography at the exposed surface of the device. Previously we developed porous, micropatterned membranes which can be applied as a lid for an islet encapsulation device and we showed that the surface topography induces human umbilical vein endothelial cell (HUVEC) alignment and interconnection. This was achieved without the addition of hydrogels, often used in angiogenesis assays. In this work, we went one step further towards clinical implementation of the device by combining this micropatterned lid with Mesenchymal Stem Cells (MSCs) to facilitate prevascularization in vivo. As for HUVECs, the micropatterned membranes induced MSC alignment and organization in vitro, an important contributor to vessel formation, whereas in vivo (subcutaneous rat model) they contributed to improved implant prevascularization. In fact, the combination of MSCs seeded on the micropatterned membrane induced the highest vessel formation score in 80% of the sections." @default.
- W2899687941 created "2018-11-16" @default.
- W2899687941 creator A5004064510 @default.
- W2899687941 creator A5006958235 @default.
- W2899687941 creator A5011577857 @default.
- W2899687941 creator A5024774533 @default.
- W2899687941 creator A5025670866 @default.
- W2899687941 creator A5030768721 @default.
- W2899687941 creator A5032135914 @default.
- W2899687941 creator A5060570396 @default.
- W2899687941 creator A5061445613 @default.
- W2899687941 creator A5084753081 @default.
- W2899687941 creator A5089225087 @default.
- W2899687941 date "2018-11-01" @default.
- W2899687941 modified "2023-10-16" @default.
- W2899687941 title "An important step towards a prevascularized islet microencapsulation device: in vivo prevascularization by combination of mesenchymal stem cells on micropatterned membranes" @default.
- W2899687941 cites W1576773659 @default.
- W2899687941 cites W1964123012 @default.
- W2899687941 cites W1967264939 @default.
- W2899687941 cites W1971387794 @default.
- W2899687941 cites W1979661817 @default.
- W2899687941 cites W1982426523 @default.
- W2899687941 cites W1985845887 @default.
- W2899687941 cites W1987794885 @default.
- W2899687941 cites W1993107030 @default.
- W2899687941 cites W1994180851 @default.
- W2899687941 cites W1997881777 @default.
- W2899687941 cites W1999228150 @default.
- W2899687941 cites W2000183303 @default.
- W2899687941 cites W2003194172 @default.
- W2899687941 cites W2005611550 @default.
- W2899687941 cites W2005948537 @default.
- W2899687941 cites W2006034240 @default.
- W2899687941 cites W2006919788 @default.
- W2899687941 cites W2011860054 @default.
- W2899687941 cites W2019646023 @default.
- W2899687941 cites W2025779728 @default.
- W2899687941 cites W2028174136 @default.
- W2899687941 cites W2029106040 @default.
- W2899687941 cites W2029721541 @default.
- W2899687941 cites W2046377580 @default.
- W2899687941 cites W2049776193 @default.
- W2899687941 cites W2051754218 @default.
- W2899687941 cites W2052318709 @default.
- W2899687941 cites W2053393023 @default.
- W2899687941 cites W2061150464 @default.
- W2899687941 cites W2061994098 @default.
- W2899687941 cites W2062972108 @default.
- W2899687941 cites W2064049827 @default.
- W2899687941 cites W2064919073 @default.
- W2899687941 cites W2067808116 @default.
- W2899687941 cites W2067906025 @default.
- W2899687941 cites W2069819213 @default.
- W2899687941 cites W2070806097 @default.
- W2899687941 cites W2072169469 @default.
- W2899687941 cites W2079496671 @default.
- W2899687941 cites W2087574307 @default.
- W2899687941 cites W2089132716 @default.
- W2899687941 cites W2089592611 @default.
- W2899687941 cites W2092786639 @default.
- W2899687941 cites W2095189993 @default.
- W2899687941 cites W2099058364 @default.
- W2899687941 cites W2104622202 @default.
- W2899687941 cites W2111812171 @default.
- W2899687941 cites W2121941471 @default.
- W2899687941 cites W2128219297 @default.
- W2899687941 cites W2128442314 @default.
- W2899687941 cites W2129387684 @default.
- W2899687941 cites W2131755176 @default.
- W2899687941 cites W2136029774 @default.
- W2899687941 cites W2144885509 @default.
- W2899687941 cites W2157295987 @default.
- W2899687941 cites W2158070939 @default.
- W2899687941 cites W2163321666 @default.
- W2899687941 cites W2163549382 @default.
- W2899687941 cites W2181342585 @default.
- W2899687941 cites W2230223647 @default.
- W2899687941 cites W2328786770 @default.
- W2899687941 cites W2332341810 @default.
- W2899687941 cites W2423855522 @default.
- W2899687941 cites W2590043924 @default.
- W2899687941 cites W2598354734 @default.
- W2899687941 cites W2747616218 @default.
- W2899687941 cites W2809699954 @default.
- W2899687941 cites W4213141530 @default.
- W2899687941 doi "https://doi.org/10.1007/s10856-018-6178-6" @default.
- W2899687941 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6244873" @default.
- W2899687941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30413974" @default.
- W2899687941 hasPublicationYear "2018" @default.
- W2899687941 type Work @default.
- W2899687941 sameAs 2899687941 @default.
- W2899687941 citedByCount "10" @default.
- W2899687941 countsByYear W28996879412019 @default.
- W2899687941 countsByYear W28996879412020 @default.
- W2899687941 countsByYear W28996879412021 @default.
- W2899687941 countsByYear W28996879412022 @default.
- W2899687941 countsByYear W28996879412023 @default.
- W2899687941 crossrefType "journal-article" @default.
- W2899687941 hasAuthorship W2899687941A5004064510 @default.
- W2899687941 hasAuthorship W2899687941A5006958235 @default.