Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899689462> ?p ?o ?g. }
- W2899689462 endingPage "1339" @default.
- W2899689462 startingPage "1323" @default.
- W2899689462 abstract "PRESENILIN 1 (PSEN1) and PRESENILIN 2 (PSEN2) genes are loci for mutations causing familial Alzheimer's disease (fAD). However, the function of these genes and how they contribute to fAD pathogenesis has not been fully determined. This review provides a summary of the overlapping and independent functions of the PRESENILINS with a focus on the lesser studied PSEN2. As a core component of the γ-secretase complex, the PSEN2 protein is involved in many γ-secretase-related physiological activities, including innate immunity, Notch signaling, autophagy, and mitochondrial function. These physiological activities have all been associated with AD progression, indicating that PSEN2 plays a particular role in AD pathogenesis." @default.
- W2899689462 created "2018-11-16" @default.
- W2899689462 creator A5043620679 @default.
- W2899689462 creator A5062613069 @default.
- W2899689462 creator A5084762480 @default.
- W2899689462 creator A5090546674 @default.
- W2899689462 date "2018-12-12" @default.
- W2899689462 modified "2023-09-23" @default.
- W2899689462 title "A Review of the Familial Alzheimer’s Disease Locus PRESENILIN 2 and Its Relationship to PRESENILIN 1" @default.
- W2899689462 cites W1501923207 @default.
- W2899689462 cites W1513242172 @default.
- W2899689462 cites W1524261859 @default.
- W2899689462 cites W1570680710 @default.
- W2899689462 cites W1593749181 @default.
- W2899689462 cites W1604262324 @default.
- W2899689462 cites W1655404681 @default.
- W2899689462 cites W1669771493 @default.
- W2899689462 cites W1675009703 @default.
- W2899689462 cites W1675105744 @default.
- W2899689462 cites W1822669487 @default.
- W2899689462 cites W1869855142 @default.
- W2899689462 cites W1919353 @default.
- W2899689462 cites W1919750748 @default.
- W2899689462 cites W1928655587 @default.
- W2899689462 cites W1963921413 @default.
- W2899689462 cites W1964102820 @default.
- W2899689462 cites W1964839543 @default.
- W2899689462 cites W1966337931 @default.
- W2899689462 cites W1966613471 @default.
- W2899689462 cites W1966694507 @default.
- W2899689462 cites W1966706283 @default.
- W2899689462 cites W1968900405 @default.
- W2899689462 cites W1970596167 @default.
- W2899689462 cites W1973884709 @default.
- W2899689462 cites W1975675335 @default.
- W2899689462 cites W1976635035 @default.
- W2899689462 cites W1978348298 @default.
- W2899689462 cites W1978566291 @default.
- W2899689462 cites W1978582104 @default.
- W2899689462 cites W1980906872 @default.
- W2899689462 cites W1983073415 @default.
- W2899689462 cites W1985501273 @default.
- W2899689462 cites W1985657116 @default.
- W2899689462 cites W1986611577 @default.
- W2899689462 cites W1988094065 @default.
- W2899689462 cites W1988855001 @default.
- W2899689462 cites W1988986946 @default.
- W2899689462 cites W1993722622 @default.
- W2899689462 cites W1994453752 @default.
- W2899689462 cites W1995434077 @default.
- W2899689462 cites W1998356763 @default.
- W2899689462 cites W1998790126 @default.
- W2899689462 cites W2001744231 @default.
- W2899689462 cites W2002057703 @default.
- W2899689462 cites W2002395888 @default.
- W2899689462 cites W2002676758 @default.
- W2899689462 cites W2004984841 @default.
- W2899689462 cites W2010484888 @default.
- W2899689462 cites W2010550564 @default.
- W2899689462 cites W2015536770 @default.
- W2899689462 cites W2016668224 @default.
- W2899689462 cites W2019676519 @default.
- W2899689462 cites W2022380909 @default.
- W2899689462 cites W2023154785 @default.
- W2899689462 cites W2023893089 @default.
- W2899689462 cites W2024454674 @default.
- W2899689462 cites W2025242397 @default.
- W2899689462 cites W2026606958 @default.
- W2899689462 cites W2029580750 @default.
- W2899689462 cites W2030749159 @default.
- W2899689462 cites W2031378173 @default.
- W2899689462 cites W2033027472 @default.
- W2899689462 cites W2034327787 @default.
- W2899689462 cites W2035587810 @default.
- W2899689462 cites W2036963269 @default.
- W2899689462 cites W2038822559 @default.
- W2899689462 cites W2041037585 @default.
- W2899689462 cites W2042778267 @default.
- W2899689462 cites W2044577531 @default.
- W2899689462 cites W2045106215 @default.
- W2899689462 cites W2045153164 @default.
- W2899689462 cites W2045860456 @default.
- W2899689462 cites W2046607232 @default.
- W2899689462 cites W2046691445 @default.
- W2899689462 cites W2052905633 @default.
- W2899689462 cites W2053351029 @default.
- W2899689462 cites W2053523069 @default.
- W2899689462 cites W2053548638 @default.
- W2899689462 cites W2053614520 @default.
- W2899689462 cites W2054040386 @default.
- W2899689462 cites W2054499580 @default.
- W2899689462 cites W2055776806 @default.
- W2899689462 cites W2056037081 @default.
- W2899689462 cites W2056064608 @default.
- W2899689462 cites W2063087670 @default.
- W2899689462 cites W2064446207 @default.
- W2899689462 cites W2064770792 @default.
- W2899689462 cites W2067471117 @default.