FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899689685> ?p ?o ?g. }

• W2899689685 endingPage "72" @default.
• W2899689685 startingPage "63" @default.
• W2899689685 abstract "Objective— Apo (apolipoprotein) CIII inhibits lipoprotein lipase (LpL)-mediated lipolysis of VLDL (very-low-density lipoprotein) triglyceride (TG) and decreases hepatic uptake of VLDL remnants. The discovery that 5% of Lancaster Old Order Amish are heterozygous for the APOC3 R19X null mutation provided the opportunity to determine the effects of a naturally occurring reduction in apo CIII levels on the metabolism of atherogenic containing lipoproteins. Approach and Results— We conducted stable isotope studies of VLDL-TG and apoB100 in 5 individuals heterozygous for the null mutation APOC3 R19X (CT) and their unaffected (CC) siblings. Fractional clearance rates and production rates of VLDL-TG and apoB100 in VLDL, IDL (intermediate-density lipoprotein), LDL, apo CIII, and apo CII were determined. Affected (CT) individuals had 49% reduction in plasma apo CIII levels compared with CCs ( P <0.01) and reduced plasma levels of TG (35%, P <0.02), VLDL-TG (45%, P <0.02), and VLDL-apoB100 (36%, P <0.05). These changes were because of higher fractional clearance rates of VLDL-TG and VLDL-apoB100 with no differences in production rates. CTs had higher rates of the conversion of VLDL remnants to LDL compared with CCs. In contrast, rates of direct removal of VLDL remnants did not differ between the groups. As a result, the flux of apoB100 from VLDL to LDL was not reduced, and the plasma levels of LDL-cholesterol and LDL-apoB100 were not lower in the CT group. Apo CIII production rate was lower in CTs compared with CCs, whereas apo CII production rate was not different between the 2 groups. The fractional clearance rates of both apo CIII and apo CII were higher in CTs than CCs. Conclusions— These studies demonstrate that 50% reductions in plasma apo CIII, in otherwise healthy subjects, results in a significantly higher rate of conversion of VLDL to LDL, with little effect on direct hepatic uptake of VLDL. When put in the context of studies demonstrating significant protection from cardiovascular events in individuals with loss of function variants in the APOC3 gene, our results provide strong evidence that therapies which increase the efficiency of conversion of VLDL to LDL, thereby reducing remnant concentrations, should reduce the risk of cardiovascular disease." @default.
• W2899689685 created "2018-11-16" @default.
• W2899689685 creator A5007048045 @default.
• W2899689685 creator A5007408007 @default.
• W2899689685 creator A5008128204 @default.
• W2899689685 creator A5008185510 @default.
• W2899689685 creator A5012063139 @default.
• W2899689685 creator A5013584099 @default.
• W2899689685 creator A5021669286 @default.
• W2899689685 creator A5024233450 @default.
• W2899689685 creator A5039806855 @default.
• W2899689685 creator A5069037391 @default.
• W2899689685 creator A5078703709 @default.
• W2899689685 creator A5086003783 @default.
• W2899689685 date "2019-01-01" @default.
• W2899689685 modified "2023-09-27" @default.
• W2899689685 title "Effects of <i>APOC3</i> Heterozygous Deficiency on Plasma Lipid and Lipoprotein Metabolism" @default.
• W2899689685 cites W1495673540 @default.
• W2899689685 cites W1527680278 @default.
• W2899689685 cites W1530283338 @default.
• W2899689685 cites W1548991782 @default.
• W2899689685 cites W1586368641 @default.
• W2899689685 cites W1607120480 @default.
• W2899689685 cites W172199271 @default.
• W2899689685 cites W1944929644 @default.
• W2899689685 cites W1963872182 @default.
• W2899689685 cites W1977395120 @default.
• W2899689685 cites W1989258056 @default.
• W2899689685 cites W2005472296 @default.
• W2899689685 cites W2012453528 @default.
• W2899689685 cites W2020686577 @default.
• W2899689685 cites W2020885344 @default.
• W2899689685 cites W2026818701 @default.
• W2899689685 cites W2029877157 @default.
• W2899689685 cites W2032456325 @default.
• W2899689685 cites W2041792934 @default.
• W2899689685 cites W2042140336 @default.
• W2899689685 cites W2042581920 @default.
• W2899689685 cites W2052586765 @default.
• W2899689685 cites W2052644460 @default.
• W2899689685 cites W2054345063 @default.
• W2899689685 cites W2057271976 @default.
• W2899689685 cites W2061100095 @default.
• W2899689685 cites W2062395148 @default.
• W2899689685 cites W2067089828 @default.
• W2899689685 cites W2078424668 @default.
• W2899689685 cites W2097893773 @default.
• W2899689685 cites W2099054337 @default.
• W2899689685 cites W2104543182 @default.
• W2899689685 cites W2108018713 @default.
• W2899689685 cites W2114808162 @default.
• W2899689685 cites W2116648398 @default.
• W2899689685 cites W2124187137 @default.
• W2899689685 cites W2124481954 @default.
• W2899689685 cites W2128293328 @default.
• W2899689685 cites W2132525699 @default.
• W2899689685 cites W2134099656 @default.
• W2899689685 cites W2134450273 @default.
• W2899689685 cites W2146425133 @default.
• W2899689685 cites W2149139434 @default.
• W2899689685 cites W2158795285 @default.
• W2899689685 cites W2160942744 @default.
• W2899689685 cites W2167351741 @default.
• W2899689685 cites W2168095967 @default.
• W2899689685 cites W2170009139 @default.
• W2899689685 cites W2170210469 @default.
• W2899689685 cites W2170925058 @default.
• W2899689685 cites W2286634515 @default.
• W2899689685 cites W2294822677 @default.
• W2899689685 cites W2297126310 @default.
• W2899689685 cites W2315899065 @default.
• W2899689685 cites W2416243525 @default.
• W2899689685 cites W2471143596 @default.
• W2899689685 cites W2510651723 @default.
• W2899689685 cites W2563852152 @default.
• W2899689685 cites W2577934204 @default.
• W2899689685 cites W2588878434 @default.
• W2899689685 cites W2605659507 @default.
• W2899689685 cites W2747264648 @default.
• W2899689685 cites W2783047364 @default.
• W2899689685 cites W4240713780 @default.
• W2899689685 cites W4244218181 @default.
• W2899689685 cites W58112070 @default.
• W2899689685 doi "https://doi.org/10.1161/atvbaha.118.311476" @default.
• W2899689685 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6309928" @default.
• W2899689685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30580564" @default.
• W2899689685 hasPublicationYear "2019" @default.
• W2899689685 type Work @default.
• W2899689685 sameAs 2899689685 @default.
• W2899689685 citedByCount "56" @default.
• W2899689685 countsByYear W28996896852019 @default.
• W2899689685 countsByYear W28996896852020 @default.
• W2899689685 countsByYear W28996896852021 @default.
• W2899689685 countsByYear W28996896852022 @default.
• W2899689685 countsByYear W28996896852023 @default.
• W2899689685 crossrefType "journal-article" @default.
• W2899689685 hasAuthorship W2899689685A5007048045 @default.
• W2899689685 hasAuthorship W2899689685A5007408007 @default.

• next