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• W2899691309 abstract "Myxofibrosarcoma (MFS) is a common soft tissue sarcoma (STS) that affects the extremities in elderly patients. The objective was to analyze the prognostic factors and outcomes of patients with MFS treated at a single institution.We retrospectively reviewed the records of 75 patients with MFS. We compared age, sex, tumor size and location, grade and stage of the disease. Median age was 49.7 years (range, 1 to 88 y).upper extremity (25.4%), lower extremity (66.6%) and pelvis (8%). Patients had high-grade tumors in 46.7% of the reports. Margins were negative in 76% of the cases. Bivariate Cox regression analysis was used to determine associations between clinical and treatment factors with local recurrence (LR).Median follow-up time was 30.7 months (range, 1.8 to 383.8 m). We found 26.7% of LR. Distant metastasis (DM) was reported in 27 (36%) patients. Lung was the most common site of DM, reported in 92.6% of patients. Overall survival (OS) with metastasis was 21.2 months (range, 4.8 to 114.8 m). Predictors of OS were grade, LR (hazard ratio [HR] 5.13, 95% confidence interval, 2.15-12.24, P <0.001), and DM (HR 540.97, 95% confidence interval, 5.04-58112.03, P< 0.001).Tumor grade, LR, positive margins and DM were significant predictors of poor OS prognosis. Level of Evidence IV, Case Series.O mixofibrossarcoma (MFS) é um sarcoma de partes moles (SPM) frequente em idosos, que afeta os membros. O objetivo foi analisar os fatores prognósticos e os desfechos dos pacientes diagnosticados com MFS em uma única instituição.Foram analisados retrospectivamente prontuários de 75 pacientes com MFS. Comparamos idade, sexo, tamanho e localização do tumor, grau histológico e o estádio da doença. A media da idade foi 49,7 anos (faixa de 1 a 88 anos).membro superior (25,4%), membro inferior (66,6%) e pelve (8%). Dos tumores, 46,7% foram de alto grau. As margens foram negativas em 76%. A análise de regressão de Cox bivariada foi usada para determinar as associações entre os fatores clínicos e de tratamento com a recorrência local (RL).A media do acompanhamento foi 30,7 meses (faixa de 1,8 a 383,8 meses) e 26,7% dos pacientes tiveram RL. Metástases a distância (MD) foram relatadas em 27 (36%) pacientes. O local mais comum de MD foi o pulmão (92,6%). A sobrevida geral (SG) com metástase foi 21,2 meses (faixa de 4,8 a 114,8 meses). Os fatores preditivos de SG foram grau, RL (razão de probabilidades [HR] 5,13, intervalo de confiança de 95%, 2,15-12,24, P < 0,001) e MD (HR 540,97, intervalo de confiança de 95%, 5,04-58.112,03, P < 0.001).Grau histológico do tumor, margens comprometidas, RL e MD foram fatores preditivos de pior prognóstico da SG. Nível de Evidencia IV, Série de Casos." @default.
• W2899691309 created "2018-11-16" @default.
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• W2899691309 date "2018-10-01" @default.
• W2899691309 modified "2023-09-23" @default.
• W2899691309 title "PROGNOSTIC FACTORS IN PATIENTS WITH APPENDICULAR MYXOFIBROSARCOMA" @default.
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• W2899691309 doi "https://doi.org/10.1590/1413-785220182605208644" @default.
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