Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899696785> ?p ?o ?g. }
- W2899696785 abstract "Abstract Cytokine genes are regulated by multiple regulatory elements that confer tissue-specific and activation-dependent expression. The cis -regulatory elements of the gene encoding IL-9, a cytokine that promotes allergy, autoimmune inflammation and tumor immunity, have not been defined. Here we identify an enhancer (CNS-25) upstream of the Il9 gene that binds most transcription factors (TFs) that promote Il9 gene expression. Deletion of the enhancer in the mouse germline alters transcription factor binding to the remaining Il9 regulatory elements, and results in diminished IL-9 production in multiple cell types including Th9 cells, and attenuates IL-9-dependent immune responses. Moreover, deletion of the homologous enhancer (CNS-18) in primary human Th9 cultures results in significant decrease of IL-9 production. Thus, Il9 CNS-25/ IL9 CNS-18 is a critical and conserved regulatory element for IL-9 production." @default.
- W2899696785 created "2018-11-16" @default.
- W2899696785 creator A5026980224 @default.
- W2899696785 creator A5030785720 @default.
- W2899696785 creator A5031780586 @default.
- W2899696785 creator A5066167699 @default.
- W2899696785 creator A5074459288 @default.
- W2899696785 creator A5081400906 @default.
- W2899696785 creator A5091077791 @default.
- W2899696785 date "2018-11-15" @default.
- W2899696785 modified "2023-10-16" @default.
- W2899696785 title "A conserved enhancer regulates Il9 expression in multiple lineages" @default.
- W2899696785 cites W1517640943 @default.
- W2899696785 cites W1526182144 @default.
- W2899696785 cites W1543604048 @default.
- W2899696785 cites W1633706547 @default.
- W2899696785 cites W1763873242 @default.
- W2899696785 cites W1925756130 @default.
- W2899696785 cites W1951972112 @default.
- W2899696785 cites W1964513680 @default.
- W2899696785 cites W1966530387 @default.
- W2899696785 cites W1971249359 @default.
- W2899696785 cites W1974168680 @default.
- W2899696785 cites W1985293294 @default.
- W2899696785 cites W1990233086 @default.
- W2899696785 cites W1992904489 @default.
- W2899696785 cites W1994954155 @default.
- W2899696785 cites W1996060670 @default.
- W2899696785 cites W2008697182 @default.
- W2899696785 cites W2012402075 @default.
- W2899696785 cites W2012825693 @default.
- W2899696785 cites W2021080331 @default.
- W2899696785 cites W2023304501 @default.
- W2899696785 cites W2026501721 @default.
- W2899696785 cites W2027347575 @default.
- W2899696785 cites W2028618405 @default.
- W2899696785 cites W2030350568 @default.
- W2899696785 cites W2030545812 @default.
- W2899696785 cites W2031593086 @default.
- W2899696785 cites W2041888438 @default.
- W2899696785 cites W2056835764 @default.
- W2899696785 cites W2075253497 @default.
- W2899696785 cites W2080152737 @default.
- W2899696785 cites W2086368962 @default.
- W2899696785 cites W2088275003 @default.
- W2899696785 cites W2089685608 @default.
- W2899696785 cites W2089987068 @default.
- W2899696785 cites W2096545973 @default.
- W2899696785 cites W2102278945 @default.
- W2899696785 cites W2111276232 @default.
- W2899696785 cites W2115050132 @default.
- W2899696785 cites W2118641214 @default.
- W2899696785 cites W2123564569 @default.
- W2899696785 cites W2124457673 @default.
- W2899696785 cites W2127350922 @default.
- W2899696785 cites W2127988376 @default.
- W2899696785 cites W2129438140 @default.
- W2899696785 cites W2136278733 @default.
- W2899696785 cites W2143980775 @default.
- W2899696785 cites W2146462066 @default.
- W2899696785 cites W2149554811 @default.
- W2899696785 cites W2151754128 @default.
- W2899696785 cites W2155651327 @default.
- W2899696785 cites W2156976032 @default.
- W2899696785 cites W2158903783 @default.
- W2899696785 cites W2161677751 @default.
- W2899696785 cites W2171808845 @default.
- W2899696785 cites W2174466696 @default.
- W2899696785 cites W2175853567 @default.
- W2899696785 cites W2345615811 @default.
- W2899696785 cites W2346568379 @default.
- W2899696785 cites W2495585516 @default.
- W2899696785 cites W2548430945 @default.
- W2899696785 cites W2564735684 @default.
- W2899696785 cites W2569675702 @default.
- W2899696785 cites W2761829407 @default.
- W2899696785 cites W2762715294 @default.
- W2899696785 cites W2783375712 @default.
- W2899696785 cites W2784110492 @default.
- W2899696785 cites W2786174959 @default.
- W2899696785 doi "https://doi.org/10.1038/s41467-018-07202-0" @default.
- W2899696785 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6237898" @default.
- W2899696785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30442929" @default.
- W2899696785 hasPublicationYear "2018" @default.
- W2899696785 type Work @default.
- W2899696785 sameAs 2899696785 @default.
- W2899696785 citedByCount "24" @default.
- W2899696785 countsByYear W28996967852019 @default.
- W2899696785 countsByYear W28996967852020 @default.
- W2899696785 countsByYear W28996967852021 @default.
- W2899696785 countsByYear W28996967852022 @default.
- W2899696785 countsByYear W28996967852023 @default.
- W2899696785 crossrefType "journal-article" @default.
- W2899696785 hasAuthorship W2899696785A5026980224 @default.
- W2899696785 hasAuthorship W2899696785A5030785720 @default.
- W2899696785 hasAuthorship W2899696785A5031780586 @default.
- W2899696785 hasAuthorship W2899696785A5066167699 @default.
- W2899696785 hasAuthorship W2899696785A5074459288 @default.
- W2899696785 hasAuthorship W2899696785A5081400906 @default.
- W2899696785 hasAuthorship W2899696785A5091077791 @default.