Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899696887> ?p ?o ?g. }
- W2899696887 endingPage "1763" @default.
- W2899696887 startingPage "1753" @default.
- W2899696887 abstract "Interactions between the prefrontal cortex (PFC) and mediodorsal thalamus are critical for cognitive flexibility, yet the underlying computations are unknown. To investigate frontothalamic substrates of cognitive flexibility, we developed a behavioral task in which mice switched between different sets of learned cues that guided attention toward either visual or auditory targets. We found that PFC responses reflected both the individual cues and their meaning as task rules, indicating a hierarchical cue-to-rule transformation. Conversely, mediodorsal thalamus responses reflected the statistical regularity of cue presentation and were required for switching between such experimentally specified cueing contexts. A subset of these thalamic responses sustained context-relevant PFC representations, while another suppressed the context-irrelevant ones. Through modeling and experimental validation, we find that thalamic-mediated suppression may not only reduce PFC representational interference but could also preserve unused cortical traces for future use. Overall, our study provides a computational foundation for thalamic engagement in cognitive flexibility." @default.
- W2899696887 created "2018-11-16" @default.
- W2899696887 creator A5003481800 @default.
- W2899696887 creator A5040065902 @default.
- W2899696887 creator A5084779684 @default.
- W2899696887 date "2018-11-19" @default.
- W2899696887 modified "2023-09-30" @default.
- W2899696887 title "Thalamic regulation of switching between cortical representations enables cognitive flexibility" @default.
- W2899696887 cites W1841190780 @default.
- W2899696887 cites W1989786687 @default.
- W2899696887 cites W1999567494 @default.
- W2899696887 cites W2005556066 @default.
- W2899696887 cites W2007502604 @default.
- W2899696887 cites W2009509151 @default.
- W2899696887 cites W2010931698 @default.
- W2899696887 cites W2022491393 @default.
- W2899696887 cites W2022881357 @default.
- W2899696887 cites W2025293658 @default.
- W2899696887 cites W2025976219 @default.
- W2899696887 cites W2028318424 @default.
- W2899696887 cites W2031023279 @default.
- W2899696887 cites W2057716394 @default.
- W2899696887 cites W2063764296 @default.
- W2899696887 cites W2069519142 @default.
- W2899696887 cites W2085773041 @default.
- W2899696887 cites W2086578108 @default.
- W2899696887 cites W2090579112 @default.
- W2899696887 cites W2096050184 @default.
- W2899696887 cites W2096539295 @default.
- W2899696887 cites W2097224904 @default.
- W2899696887 cites W2097372834 @default.
- W2899696887 cites W2102138781 @default.
- W2899696887 cites W2103179919 @default.
- W2899696887 cites W2104433015 @default.
- W2899696887 cites W2127780691 @default.
- W2899696887 cites W2128552517 @default.
- W2899696887 cites W2133510276 @default.
- W2899696887 cites W2151137320 @default.
- W2899696887 cites W2152868521 @default.
- W2899696887 cites W2157380881 @default.
- W2899696887 cites W2160360511 @default.
- W2899696887 cites W2207801098 @default.
- W2899696887 cites W2239211889 @default.
- W2899696887 cites W2414006382 @default.
- W2899696887 cites W2503929286 @default.
- W2899696887 cites W2523714899 @default.
- W2899696887 cites W2560647685 @default.
- W2899696887 cites W2567727905 @default.
- W2899696887 cites W2587143268 @default.
- W2899696887 cites W2610186267 @default.
- W2899696887 cites W2611485120 @default.
- W2899696887 cites W2618100165 @default.
- W2899696887 cites W2738724892 @default.
- W2899696887 cites W2738950689 @default.
- W2899696887 cites W2756375591 @default.
- W2899696887 cites W2763321637 @default.
- W2899696887 cites W2769987702 @default.
- W2899696887 cites W2774489697 @default.
- W2899696887 cites W2786406982 @default.
- W2899696887 cites W2787295326 @default.
- W2899696887 cites W2787499237 @default.
- W2899696887 cites W2796035370 @default.
- W2899696887 cites W2803771456 @default.
- W2899696887 cites W2949634824 @default.
- W2899696887 cites W4255885670 @default.
- W2899696887 doi "https://doi.org/10.1038/s41593-018-0269-z" @default.
- W2899696887 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7225728" @default.
- W2899696887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30455456" @default.
- W2899696887 hasPublicationYear "2018" @default.
- W2899696887 type Work @default.
- W2899696887 sameAs 2899696887 @default.
- W2899696887 citedByCount "169" @default.
- W2899696887 countsByYear W28996968872017 @default.
- W2899696887 countsByYear W28996968872019 @default.
- W2899696887 countsByYear W28996968872020 @default.
- W2899696887 countsByYear W28996968872021 @default.
- W2899696887 countsByYear W28996968872022 @default.
- W2899696887 countsByYear W28996968872023 @default.
- W2899696887 crossrefType "journal-article" @default.
- W2899696887 hasAuthorship W2899696887A5003481800 @default.
- W2899696887 hasAuthorship W2899696887A5040065902 @default.
- W2899696887 hasAuthorship W2899696887A5084779684 @default.
- W2899696887 hasBestOaLocation W28996968872 @default.
- W2899696887 hasConcept C105795698 @default.
- W2899696887 hasConcept C151730666 @default.
- W2899696887 hasConcept C15744967 @default.
- W2899696887 hasConcept C162324750 @default.
- W2899696887 hasConcept C169760540 @default.
- W2899696887 hasConcept C169900460 @default.
- W2899696887 hasConcept C180747234 @default.
- W2899696887 hasConcept C187736073 @default.
- W2899696887 hasConcept C2779246727 @default.
- W2899696887 hasConcept C2779343474 @default.
- W2899696887 hasConcept C2780451532 @default.
- W2899696887 hasConcept C2780598303 @default.
- W2899696887 hasConcept C2781195155 @default.
- W2899696887 hasConcept C33923547 @default.
- W2899696887 hasConcept C66102695 @default.