FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899698008> ?p ?o ?g. }

• W2899698008 endingPage "112" @default.
• W2899698008 startingPage "103" @default.
• W2899698008 abstract "MicroRNAs (miRNAs) play a critical role on biological and cellular processes; the search for functional markers may be of importance for differential diagnosis, prognosis, and development of new therapeutic regimens. In this context, we evaluated the bone marrow miRNA profile of Brazilian children exhibiting T- or B-cell acute lymphoblastic leukemia (T-ALL or B-ALL), using massive parallel sequencing, using the HiSeq 2500 platform (Illumina). The differential expression analysis was conducted considering a leave-one-out approach and FDR ≤ 0.05. Machine learning algorithms were applied to search for the disease subset biomarkers. Target prediction, functional enrichment, and classification of biological categories were also performed. Sixteen miRNAs were differentially expressed between T- and B-ALL, of which 10 (miR-708-5p, miR-497-5p, miR-151a-5p, miR-151b, miR-371b-5p, miR-455-5p, miR-195-5p, miR-1266-5p, miR-574-5p, and miR-425-5p) were downregulated and six (miR-450b-5p, miR-450a-5p, miR-542-5p, miR-424-5p, miR-629-5p, and miR-29c-5p) were upregulated in childhood T-ALL. These miRNAs may be used for distinguishing childhood lymphoblastic leukemia subtypes, since it provided the clear separation of patients in these two distinct groups. Six relevant biological pathways were identified according to their role in leukemia, namely, viral carcinogenesis, cell cycle, and B-cell receptor signaling pathways for induced miRNAs and TGF-beta signaling, apoptosis, and NF-kappa B signaling for the repressed miRNAs, of which several miRNA gene targets participate in cell differentiation and hematopoiesis processes. Machine learning analysis pointed out miR-29c-5p expression as the best discriminator between childhood T- and B-ALL, which is involved in calcium signaling, critical for B-cell lymphocyte fate. Further studies are needed to assure the role of the 16 miRNAs and miR-29c-5p on acute lymphoblastic leukemia subtypes and on disease prognosis." @default.
• W2899698008 created "2018-11-16" @default.
• W2899698008 creator A5003105433 @default.
• W2899698008 creator A5006275227 @default.
• W2899698008 creator A5019742774 @default.
• W2899698008 creator A5053152034 @default.
• W2899698008 creator A5061587246 @default.
• W2899698008 creator A5065833399 @default.
• W2899698008 creator A5074575863 @default.
• W2899698008 creator A5076241242 @default.
• W2899698008 date "2018-11-27" @default.
• W2899698008 modified "2023-10-15" @default.
• W2899698008 title "MicroRNA expression profiles discriminate childhood T‐ from B‐acute lymphoblastic leukemia" @default.
• W2899698008 cites W144423133 @default.
• W2899698008 cites W1519245680 @default.
• W2899698008 cites W1530562813 @default.
• W2899698008 cites W1609108695 @default.
• W2899698008 cites W1969280128 @default.
• W2899698008 cites W1980409815 @default.
• W2899698008 cites W1983771472 @default.
• W2899698008 cites W1985405118 @default.
• W2899698008 cites W1989593746 @default.
• W2899698008 cites W1993345998 @default.
• W2899698008 cites W2000977869 @default.
• W2899698008 cites W2001235967 @default.
• W2899698008 cites W2013921359 @default.
• W2899698008 cites W2024290860 @default.
• W2899698008 cites W2030596204 @default.
• W2899698008 cites W2032095580 @default.
• W2899698008 cites W2032311668 @default.
• W2899698008 cites W2032553162 @default.
• W2899698008 cites W2036897871 @default.
• W2899698008 cites W2057346914 @default.
• W2899698008 cites W2058786179 @default.
• W2899698008 cites W2061638986 @default.
• W2899698008 cites W2063123633 @default.
• W2899698008 cites W2075329854 @default.
• W2899698008 cites W2077327925 @default.
• W2899698008 cites W2077830421 @default.
• W2899698008 cites W2078493126 @default.
• W2899698008 cites W2083913805 @default.
• W2899698008 cites W2093393962 @default.
• W2899698008 cites W2093963603 @default.
• W2899698008 cites W2107277218 @default.
• W2899698008 cites W2112192177 @default.
• W2899698008 cites W2114104545 @default.
• W2899698008 cites W2130979840 @default.
• W2899698008 cites W2134296432 @default.
• W2899698008 cites W2141086871 @default.
• W2899698008 cites W2147495091 @default.
• W2899698008 cites W2150113701 @default.
• W2899698008 cites W2150548551 @default.
• W2899698008 cites W2160844806 @default.
• W2899698008 cites W2170400030 @default.
• W2899698008 cites W2171211339 @default.
• W2899698008 cites W2209604420 @default.
• W2899698008 cites W2338179315 @default.
• W2899698008 cites W2341887262 @default.
• W2899698008 cites W2558715006 @default.
• W2899698008 cites W2571277139 @default.
• W2899698008 cites W2591353532 @default.
• W2899698008 cites W2736520162 @default.
• W2899698008 cites W2742440435 @default.
• W2899698008 cites W2744441486 @default.
• W2899698008 cites W2752421630 @default.
• W2899698008 doi "https://doi.org/10.1002/hon.2567" @default.
• W2899698008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30393877" @default.
• W2899698008 hasPublicationYear "2018" @default.
• W2899698008 type Work @default.
• W2899698008 sameAs 2899698008 @default.
• W2899698008 citedByCount "37" @default.
• W2899698008 countsByYear W28996980082019 @default.
• W2899698008 countsByYear W28996980082020 @default.
• W2899698008 countsByYear W28996980082021 @default.
• W2899698008 countsByYear W28996980082022 @default.
• W2899698008 countsByYear W28996980082023 @default.
• W2899698008 crossrefType "journal-article" @default.
• W2899698008 hasAuthorship W2899698008A5003105433 @default.
• W2899698008 hasAuthorship W2899698008A5006275227 @default.
• W2899698008 hasAuthorship W2899698008A5019742774 @default.
• W2899698008 hasAuthorship W2899698008A5053152034 @default.
• W2899698008 hasAuthorship W2899698008A5061587246 @default.
• W2899698008 hasAuthorship W2899698008A5065833399 @default.
• W2899698008 hasAuthorship W2899698008A5074575863 @default.
• W2899698008 hasAuthorship W2899698008A5076241242 @default.
• W2899698008 hasBestOaLocation W28996980081 @default.
• W2899698008 hasConcept C104317684 @default.
• W2899698008 hasConcept C127561419 @default.
• W2899698008 hasConcept C145059251 @default.
• W2899698008 hasConcept C151730666 @default.
• W2899698008 hasConcept C203014093 @default.
• W2899698008 hasConcept C2778461978 @default.
• W2899698008 hasConcept C2779343474 @default.
• W2899698008 hasConcept C502942594 @default.
• W2899698008 hasConcept C54355233 @default.
• W2899698008 hasConcept C555283112 @default.
• W2899698008 hasConcept C62478195 @default.
• W2899698008 hasConcept C70721500 @default.

• next