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• W2899704004 abstract "ABSTRACT Lysine acetylation is an epigenetic mark that is principally recognized by bromodomains and recently structurally diverse YEATS domains also emerged as readers of lysine acetyl/acylations. Here we present a crystallography-based strategy and the discovery of fragments binding to the ENL YEATS domain, a potential drug target. Crystal structures combined with synthetic efforts led to the identification of a sub-micromolar binder, providing first starting points for the development of chemical probes for this reader domain family." @default.
• W2899704004 created "2018-11-16" @default.
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• W2899704004 date "2018-11-08" @default.
• W2899704004 modified "2023-09-27" @default.
• W2899704004 title "A structure-based approach towards identification of inhibitory fragments for eleven-nineteen-leukemia protein (ENL) YEATS domain" @default.
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• W2899704004 doi "https://doi.org/10.1101/466284" @default.
• W2899704004 hasPublicationYear "2018" @default.
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