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- W2899721211 startingPage "1221" @default.
- W2899721211 abstract "The main inconvenience of conventional eye drops is the rapid washout of the drugs due to nasolacrimal drainage or ophthalmic barriers. The ocular drug bioavailability can be improved by either prolonging retention time in the cul-de-sac or by increasing the ocular permeability. The focus of this review is to highlight some chitosan-based drug delivery approaches that proved to have good clinical efficacy and high potential for use in ophthalmology. They are exemplified by recent studies exploring in-depth the techniques and mechanisms in order to improve ocular bioavailability of the active substances. Used alone or in combination with other compounds with synergistic action, chitosan enables ocular retention time and corneal permeability. Associated with other stimuli-responsive polymers, it enhances the mechanical strength of the gels. Chitosan and its derivatives increase drug permeability through the cornea by temporarily opening tight junctions between epithelial cells. Different types of chitosan-based colloidal systems have the potential to overcome the ocular barriers without disturbing the vision process. Chitosan also plays a key role in improving corneal wound healing by stimulating the migration of keratinocytes when it is used alone or in combination with other compounds with synergistic action." @default.
- W2899721211 created "2018-11-16" @default.
- W2899721211 creator A5007754084 @default.
- W2899721211 creator A5015553981 @default.
- W2899721211 creator A5040648525 @default.
- W2899721211 creator A5042883373 @default.
- W2899721211 creator A5068033631 @default.
- W2899721211 creator A5084318183 @default.
- W2899721211 date "2018-11-03" @default.
- W2899721211 modified "2023-10-16" @default.
- W2899721211 title "Strategies for Improving Ocular Drug Bioavailability and Corneal Wound Healing with Chitosan-Based Delivery Systems" @default.
- W2899721211 cites W142830980 @default.
- W2899721211 cites W1475796694 @default.
- W2899721211 cites W1499024107 @default.
- W2899721211 cites W1671620727 @default.
- W2899721211 cites W1877301297 @default.
- W2899721211 cites W1949073676 @default.
- W2899721211 cites W1964440956 @default.
- W2899721211 cites W1967384297 @default.
- W2899721211 cites W1969666381 @default.
- W2899721211 cites W1970440361 @default.
- W2899721211 cites W1970666911 @default.
- W2899721211 cites W1973459657 @default.
- W2899721211 cites W1974723991 @default.
- W2899721211 cites W1976372264 @default.
- W2899721211 cites W1976845238 @default.
- W2899721211 cites W1988413525 @default.
- W2899721211 cites W1994660331 @default.
- W2899721211 cites W1997154876 @default.
- W2899721211 cites W1998259722 @default.
- W2899721211 cites W2003536321 @default.
- W2899721211 cites W2013134736 @default.
- W2899721211 cites W2013336732 @default.
- W2899721211 cites W2014144868 @default.
- W2899721211 cites W2016571186 @default.
- W2899721211 cites W2018516156 @default.
- W2899721211 cites W2019829312 @default.
- W2899721211 cites W2020473652 @default.
- W2899721211 cites W2021152168 @default.
- W2899721211 cites W2025914685 @default.
- W2899721211 cites W2034800636 @default.
- W2899721211 cites W2037701992 @default.
- W2899721211 cites W2041880062 @default.
- W2899721211 cites W2043349112 @default.
- W2899721211 cites W2049818440 @default.
- W2899721211 cites W2053724045 @default.
- W2899721211 cites W2056733262 @default.
- W2899721211 cites W2059676438 @default.
- W2899721211 cites W2063110356 @default.
- W2899721211 cites W2064301088 @default.
- W2899721211 cites W2065374943 @default.
- W2899721211 cites W2065837838 @default.
- W2899721211 cites W2067927620 @default.
- W2899721211 cites W2068471000 @default.
- W2899721211 cites W2072216113 @default.
- W2899721211 cites W2074585568 @default.
- W2899721211 cites W2074822022 @default.
- W2899721211 cites W2077799930 @default.
- W2899721211 cites W2077912787 @default.
- W2899721211 cites W2078835510 @default.
- W2899721211 cites W2085500609 @default.
- W2899721211 cites W2085648623 @default.
- W2899721211 cites W2086757310 @default.
- W2899721211 cites W2086775219 @default.
- W2899721211 cites W2090044999 @default.
- W2899721211 cites W2091403293 @default.
- W2899721211 cites W2093134606 @default.
- W2899721211 cites W2097603366 @default.
- W2899721211 cites W2099930528 @default.
- W2899721211 cites W2111771198 @default.
- W2899721211 cites W2114018039 @default.
- W2899721211 cites W2119132884 @default.
- W2899721211 cites W2123118282 @default.
- W2899721211 cites W2136528478 @default.
- W2899721211 cites W2139516405 @default.
- W2899721211 cites W2146718592 @default.
- W2899721211 cites W2148638984 @default.
- W2899721211 cites W2153324098 @default.
- W2899721211 cites W2154899729 @default.
- W2899721211 cites W2157634286 @default.
- W2899721211 cites W2158643446 @default.
- W2899721211 cites W2161708416 @default.
- W2899721211 cites W2170101626 @default.
- W2899721211 cites W2218345709 @default.
- W2899721211 cites W2266732512 @default.
- W2899721211 cites W2284342326 @default.
- W2899721211 cites W2291473961 @default.
- W2899721211 cites W2291567557 @default.
- W2899721211 cites W2307645079 @default.
- W2899721211 cites W2324350546 @default.
- W2899721211 cites W2331666195 @default.
- W2899721211 cites W2342657716 @default.
- W2899721211 cites W2409886329 @default.
- W2899721211 cites W2463744290 @default.
- W2899721211 cites W2473852548 @default.
- W2899721211 cites W2481235900 @default.
- W2899721211 cites W2502217397 @default.
- W2899721211 cites W2536698167 @default.