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- W2899726908 abstract "Abstract New therapeutics are urgently needed to fight tuberculosis and mycobacteria‐related diseases that are a major health hazard especially in poor countries. Natural products have been the source of important antitubercular drugs in the past and still need to receive attention as a potent reservoir of chemical structures. Fifteen known and two new (+)‐usnic acid (a benzofurandione formerly isolated from lichens) enamines and hydrazones are here described and tested against sensitive and multidrug‐resistant strains of mycobacteria. Among several (+)‐usnic acid conjugates, PS14 and PS18 showed potent activity against both susceptible and resistant Mycobacterium tuberculosis strains (MIC values of 1–32 and 2–32 mg/L, respectively) comparable with MIC of other antitubercular drugs already in use for tuberculosis treatment." @default.
- W2899726908 created "2018-11-16" @default.
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- W2899726908 date "2018-11-08" @default.
- W2899726908 modified "2023-09-27" @default.
- W2899726908 title "Synthesis and antimycobacterial activity of (+)-usnic acid conjugates" @default.
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- W2899726908 doi "https://doi.org/10.1002/ardp.201800177" @default.
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