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- W2899732007 abstract "ABCC6 is a member of the C subfamily of ATP-binding cassette transporters whose mutations are correlated to Pseudoxanthoma elasticum, an autosomal recessive, progressive disorder characterized by ectopic mineralization and fragmentation of elastic fibers. Structural studies of the entire protein have been hindered by its large size, membrane association, and domain complexity. Studies previously performed have contributed to shed light on the structure and function of the nucleotide binding domains and of the N-terminal region. Here we report the expression in E. coli of the polypeptide E205-G279 contained in the cytoplasmic L0 loop. For the first time structural studies in solution were performed. Far-UV CD spectra showed that L0 is structured, assuming predominantly α-helix in TFE solution and turns in phosphate buffer. Fluorescence spectra indicated some flexibility of the regions containing aromatic residues. 1H NMR spectroscopy identified three helical regions separated by more flexible regions." @default.
- W2899732007 created "2018-11-16" @default.
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- W2899732007 date "2019-02-01" @default.
- W2899732007 modified "2023-09-23" @default.
- W2899732007 title "Structural characterization of the L0 cytoplasmic loop of human multidrug resistance protein 6 (MRP6)" @default.
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- W2899732007 doi "https://doi.org/10.1016/j.bbamem.2018.11.002" @default.
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