FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899732012> ?p ?o ?g. }

• W2899732012 endingPage "430a" @default.
• W2899732012 startingPage "430a" @default.
• W2899732012 abstract "The ability of a cell population to maintain simultaneously multiple phenotypic states is crucial for cell fitness. It is well known that the presence of a positive feedback is sufficient to generate multistability. However, many transcription networks contain counteracting positive and negative feedbacks, which indicates that this multiloop design provides additional advantages. Through an experimental and computational study in an interlinked positive and negative feedback motif in which each feedback strength is modulate independently, we explore the dynamic properties of this interlinked network. Our results show that the transition rates between different phenotypic states are not modulated by the positive, but only by the negative feedback strength. These results indicate that the negative feedback strength determines the phenotypic behavior of the cell populations, modulating the range and stability of different multistable states. By measuring noise levels in mRNA expression we show that this differential behavior is possible because noise levels are modulated independently by each feedback motif inside this genetic network. This suggests that in this coupled design, the strength of the negative feedback loop may be tuned to allow a population to enhance its fitness by changing the rate of stochastic transitions between different states, thus ensuring that cells may be prepared to confront a given level of environmental fluctuations." @default.
• W2899732012 created "2018-11-16" @default.
• W2899732012 creator A5003741342 @default.
• W2899732012 creator A5010997076 @default.
• W2899732012 creator A5035202405 @default.
• W2899732012 creator A5040255064 @default.
• W2899732012 date "2010-01-01" @default.
• W2899732012 modified "2023-10-07" @default.
• W2899732012 title "Tuning the Range and Stability of Multiple Phenotypic States with Coupled Positive-Negative Feedback Loops" @default.
• W2899732012 doi "https://doi.org/10.1016/j.bpj.2009.12.2330" @default.
• W2899732012 hasPublicationYear "2010" @default.
• W2899732012 type Work @default.
• W2899732012 sameAs 2899732012 @default.
• W2899732012 citedByCount "0" @default.
• W2899732012 crossrefType "journal-article" @default.
• W2899732012 hasAuthorship W2899732012A5003741342 @default.
• W2899732012 hasAuthorship W2899732012A5010997076 @default.
• W2899732012 hasAuthorship W2899732012A5035202405 @default.
• W2899732012 hasAuthorship W2899732012A5040255064 @default.
• W2899732012 hasBestOaLocation W28997320121 @default.
• W2899732012 hasConcept C104317684 @default.
• W2899732012 hasConcept C119599485 @default.
• W2899732012 hasConcept C121332964 @default.
• W2899732012 hasConcept C121864883 @default.
• W2899732012 hasConcept C127413603 @default.
• W2899732012 hasConcept C127716648 @default.
• W2899732012 hasConcept C144024400 @default.
• W2899732012 hasConcept C149923435 @default.
• W2899732012 hasConcept C154945302 @default.
• W2899732012 hasConcept C158622935 @default.
• W2899732012 hasConcept C165801399 @default.
• W2899732012 hasConcept C186060115 @default.
• W2899732012 hasConcept C186886427 @default.
• W2899732012 hasConcept C2775924081 @default.
• W2899732012 hasConcept C2776966350 @default.
• W2899732012 hasConcept C2908647359 @default.
• W2899732012 hasConcept C2986044853 @default.
• W2899732012 hasConcept C38652104 @default.
• W2899732012 hasConcept C41008148 @default.
• W2899732012 hasConcept C47446073 @default.
• W2899732012 hasConcept C48207687 @default.
• W2899732012 hasConcept C54355233 @default.
• W2899732012 hasConcept C62520636 @default.
• W2899732012 hasConcept C86803240 @default.
• W2899732012 hasConcept C93586867 @default.
• W2899732012 hasConceptScore W2899732012C104317684 @default.
• W2899732012 hasConceptScore W2899732012C119599485 @default.
• W2899732012 hasConceptScore W2899732012C121332964 @default.
• W2899732012 hasConceptScore W2899732012C121864883 @default.
• W2899732012 hasConceptScore W2899732012C127413603 @default.
• W2899732012 hasConceptScore W2899732012C127716648 @default.
• W2899732012 hasConceptScore W2899732012C144024400 @default.
• W2899732012 hasConceptScore W2899732012C149923435 @default.
• W2899732012 hasConceptScore W2899732012C154945302 @default.
• W2899732012 hasConceptScore W2899732012C158622935 @default.
• W2899732012 hasConceptScore W2899732012C165801399 @default.
• W2899732012 hasConceptScore W2899732012C186060115 @default.
• W2899732012 hasConceptScore W2899732012C186886427 @default.
• W2899732012 hasConceptScore W2899732012C2775924081 @default.
• W2899732012 hasConceptScore W2899732012C2776966350 @default.
• W2899732012 hasConceptScore W2899732012C2908647359 @default.
• W2899732012 hasConceptScore W2899732012C2986044853 @default.
• W2899732012 hasConceptScore W2899732012C38652104 @default.
• W2899732012 hasConceptScore W2899732012C41008148 @default.
• W2899732012 hasConceptScore W2899732012C47446073 @default.
• W2899732012 hasConceptScore W2899732012C48207687 @default.
• W2899732012 hasConceptScore W2899732012C54355233 @default.
• W2899732012 hasConceptScore W2899732012C62520636 @default.
• W2899732012 hasConceptScore W2899732012C86803240 @default.
• W2899732012 hasConceptScore W2899732012C93586867 @default.
• W2899732012 hasIssue "3" @default.
• W2899732012 hasLocation W28997320121 @default.
• W2899732012 hasOpenAccess W2899732012 @default.
• W2899732012 hasPrimaryLocation W28997320121 @default.
• W2899732012 hasRelatedWork W1970070519 @default.
• W2899732012 hasRelatedWork W1996912812 @default.
• W2899732012 hasRelatedWork W2001053085 @default.
• W2899732012 hasRelatedWork W2024922461 @default.
• W2899732012 hasRelatedWork W2027733508 @default.
• W2899732012 hasRelatedWork W2029939011 @default.
• W2899732012 hasRelatedWork W2032674711 @default.
• W2899732012 hasRelatedWork W2043897351 @default.
• W2899732012 hasRelatedWork W2053610817 @default.
• W2899732012 hasRelatedWork W2067368644 @default.
• W2899732012 hasRelatedWork W2098501743 @default.
• W2899732012 hasRelatedWork W2108876863 @default.
• W2899732012 hasRelatedWork W2122677926 @default.
• W2899732012 hasRelatedWork W2149884465 @default.
• W2899732012 hasRelatedWork W2157121469 @default.
• W2899732012 hasRelatedWork W2157287552 @default.
• W2899732012 hasRelatedWork W2286529296 @default.
• W2899732012 hasRelatedWork W2800575961 @default.
• W2899732012 hasRelatedWork W2899244556 @default.
• W2899732012 hasRelatedWork W2952159390 @default.
• W2899732012 hasVolume "98" @default.
• W2899732012 isParatext "false" @default.
• W2899732012 isRetracted "false" @default.
• W2899732012 magId "2899732012" @default.

• next