FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899752413> ?p ?o ?g. }

• W2899752413 endingPage "325" @default.
• W2899752413 startingPage "314" @default.
• W2899752413 abstract "The dopamine (DA) system plays an important role in cognition. Accordingly, normal variation in DA genes has been found to predict individual differences in cognitive performance. However, little is known of the impact of genetic differences on the link between empirical indicators of the DA system and cognition in humans. The present work used PET with 11 C-raclopride to assess DA D2-receptor binding potential (BP) and links to episodic memory, working memory, and perceptual speed in 179 healthy adults aged 64–68 years. Previously, the T-allele of a DA D2-receptor single-nucleotide polymorphism, C957T, was associated with increased apparent affinity of 11 C-raclopride, giving rise to higher BP values despite similar receptor density values between allelic groups. Consequently, we hypothesized that 11 C-raclopride BP measures inflated by affinity rather than D2-receptor density in T-allele carriers would not be predictive of DA integrity and therefore prevent finding an association between 11 C-raclopride BP and cognitive performance. In accordance with previous findings, we show that 11 C-raclopride BP was increased in T-homozygotes. Importantly, 11 C-raclopride BP was only associated with cognitive performance in groups with low or average ligand affinity (C-allele carriers of C957T, n = 124), but not in the high-affinity group (T-homozygotes, n = 55). The strongest 11 C-raclopride BP–cognition associations and the highest level of performance were found in C-homozygotes. These findings show that genetic differences modulate the link between BP and cognition and thus have important implications for the interpretation of DA assessments with PET and 11 C-raclopride in multiple disciplines ranging from cognitive neuroscience to psychiatry and neurology." @default.
• W2899752413 created "2018-11-16" @default.
• W2899752413 creator A5008745650 @default.
• W2899752413 creator A5027164286 @default.
• W2899752413 creator A5029341444 @default.
• W2899752413 creator A5051550363 @default.
• W2899752413 creator A5066498823 @default.
• W2899752413 creator A5066511637 @default.
• W2899752413 creator A5068408229 @default.
• W2899752413 creator A5071038364 @default.
• W2899752413 creator A5077783697 @default.
• W2899752413 creator A5084761067 @default.
• W2899752413 creator A5084783384 @default.
• W2899752413 date "2019-02-01" @default.
• W2899752413 modified "2023-10-03" @default.
• W2899752413 title "<i>C957T</i>-mediated Variation in Ligand Affinity Affects the Association between¹¹C-raclopride Binding Potential and Cognition" @default.
• W2899752413 cites W1527753734 @default.
• W2899752413 cites W1921980981 @default.
• W2899752413 cites W1923399679 @default.
• W2899752413 cites W1966074045 @default.
• W2899752413 cites W1967223793 @default.
• W2899752413 cites W1970453159 @default.
• W2899752413 cites W1972010893 @default.
• W2899752413 cites W1977293177 @default.
• W2899752413 cites W1977634040 @default.
• W2899752413 cites W1979104282 @default.
• W2899752413 cites W1983804154 @default.
• W2899752413 cites W1988100039 @default.
• W2899752413 cites W1995033222 @default.
• W2899752413 cites W2002834809 @default.
• W2899752413 cites W2004293194 @default.
• W2899752413 cites W2006931708 @default.
• W2899752413 cites W2008697344 @default.
• W2899752413 cites W2009676467 @default.
• W2899752413 cites W2015763500 @default.
• W2899752413 cites W2020524474 @default.
• W2899752413 cites W2020815963 @default.
• W2899752413 cites W2028402362 @default.
• W2899752413 cites W2034482043 @default.
• W2899752413 cites W2038444868 @default.
• W2899752413 cites W2042331277 @default.
• W2899752413 cites W2054230322 @default.
• W2899752413 cites W2054929374 @default.
• W2899752413 cites W2062990061 @default.
• W2899752413 cites W2063017390 @default.
• W2899752413 cites W2063418424 @default.
• W2899752413 cites W2066735646 @default.
• W2899752413 cites W2070558694 @default.
• W2899752413 cites W2070928772 @default.
• W2899752413 cites W2071679295 @default.
• W2899752413 cites W2075362165 @default.
• W2899752413 cites W2076037568 @default.
• W2899752413 cites W2076309324 @default.
• W2899752413 cites W2082638532 @default.
• W2899752413 cites W2085494338 @default.
• W2899752413 cites W2087809804 @default.
• W2899752413 cites W2087958302 @default.
• W2899752413 cites W2090291844 @default.
• W2899752413 cites W2092058606 @default.
• W2899752413 cites W2094134651 @default.
• W2899752413 cites W2101135654 @default.
• W2899752413 cites W2102098190 @default.
• W2899752413 cites W2103493168 @default.
• W2899752413 cites W2112278807 @default.
• W2899752413 cites W2120419552 @default.
• W2899752413 cites W2121887890 @default.
• W2899752413 cites W2124190705 @default.
• W2899752413 cites W2128446887 @default.
• W2899752413 cites W2130816992 @default.
• W2899752413 cites W2135748590 @default.
• W2899752413 cites W2137412250 @default.
• W2899752413 cites W2139157312 @default.
• W2899752413 cites W2141743203 @default.
• W2899752413 cites W2145602532 @default.
• W2899752413 cites W2152550799 @default.
• W2899752413 cites W2155298532 @default.
• W2899752413 cites W2155659014 @default.
• W2899752413 cites W2162809807 @default.
• W2899752413 cites W2170823745 @default.
• W2899752413 cites W2469116017 @default.
• W2899752413 cites W2473634812 @default.
• W2899752413 cites W2487432485 @default.
• W2899752413 cites W2489904471 @default.
• W2899752413 cites W2607431938 @default.
• W2899752413 cites W2917847653 @default.
• W2899752413 cites W4254563237 @default.
• W2899752413 cites W4299350012 @default.
• W2899752413 doi "https://doi.org/10.1162/jocn_a_01354" @default.
• W2899752413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30407135" @default.
• W2899752413 hasPublicationYear "2019" @default.
• W2899752413 type Work @default.
• W2899752413 sameAs 2899752413 @default.
• W2899752413 citedByCount "12" @default.
• W2899752413 countsByYear W28997524132018 @default.
• W2899752413 countsByYear W28997524132019 @default.
• W2899752413 countsByYear W28997524132021 @default.
• W2899752413 countsByYear W28997524132022 @default.
• W2899752413 countsByYear W28997524132023 @default.

• next