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- W2899761586 abstract "The synthesis of ribosomal subunits in eukaryotes requires the interplay of numerous maturation and assembly factors (AFs) that intervene in the insertion of ribosomal proteins within pre‐ribosomal particles, the ribosomal subunit precursors, as well as in pre‐ribosomal RNA (rRNA) processing and folding. Here, we review the intricate nuclear and cytoplasmic maturation steps of pre‐40S particles, the precursors to the small ribosomal subunits, in both yeast and human cells, with particular emphasis on the timing and mechanisms of AF association with and dissociation from pre‐40S particles and the roles of these AFs in the maturation process. We highlight the particularly complex pre‐rRNA processing pathway in human cells, compared to yeast, to generate the mature 18S rRNA. We discuss the information gained from the recently published cryo‐electron microscopy atomic models of yeast and human pre‐40S particles, as well as the checkpoint/quality control systems that seem to operate to probe functional sites within yeast cytoplasmic pre‐40S particles. This article is categorized under: RNA Processing > rRNA Processing Translation > Ribosome Biogenesis" @default.
- W2899761586 created "2018-11-16" @default.
- W2899761586 creator A5007113192 @default.
- W2899761586 creator A5036145020 @default.
- W2899761586 creator A5046752606 @default.
- W2899761586 creator A5059364853 @default.
- W2899761586 creator A5061549098 @default.
- W2899761586 creator A5071639794 @default.
- W2899761586 creator A5075574996 @default.
- W2899761586 creator A5089322890 @default.
- W2899761586 date "2018-11-08" @default.
- W2899761586 modified "2023-10-17" @default.
- W2899761586 title "Maturation of pre‐40S particles in yeast and humans" @default.
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