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• W2899763513 abstract "Purpose Explore etiology, clinical course and outcome of infant epilepsy in Bhumibol Adulyadej Hospital. Method Retrospective and prospective descriptive analysis of infants 1 month to 1 year diagnosed with epilepsy between January 1, 2012, and April 30, 2018. Results Total 57 infants. Average age of seizure onset was 4.7 months. Follow-up period averaged 34.2 months. Prenatal risk factors were found in 28.1 percent (16/57). Of these, 50 percent (8/16) had seizure in neonatal period. An additional 6 infants without any prenatal risk factor had seizure in the neonatal period, bringing the total newborn with seizure to 24.6 percent (14/57). Family history of seizure was positive in only 15.8 percent (9/57). Neuroimaging was done 68.4 percent (39/57) and electroencephalogram 50.9 percent (29/57). The etiology was mostly structural 38.6 percent (22/57), followed by unknown 35.1 percent (20/57), genetics 14 percent (8/57), infection 10.5 percent (6/57) and metabolic 1.8 percent (1/57). Status epilepticus was found 21.1 percent of the times (12/57). Antiepileptic drugs were discontinued 19.3 percent (11/57). Intractable seizure was found 29.8 percent (17/57) and developmental delay 56.1 percent (32/57). By multivariate logistic regression analysis, status epilepticus and developmental delay predicted intractable seizure, whereas, abnormal neurological examination and abnormal neuroimaging predicted developmental delay. Mortality rate was 3.5 percent. Conclusion The study shows that early onset of epilepsy in children under a year is similar to that found in children less than 2–3 years as found in prior studies. High percentages of intractable seizure and developmental delay were found." @default.
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• W2899763513 date "2019-01-01" @default.
• W2899763513 modified "2023-09-26" @default.
• W2899763513 title "Etiology, clinical course and outcome of infant epilepsy: Experience of a tertiary center in Thailand" @default.
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• W2899763513 doi "https://doi.org/10.1016/j.jocn.2018.10.117" @default.
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