FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899784297> ?p ?o ?g. }

• W2899784297 endingPage "257" @default.
• W2899784297 startingPage "250" @default.
• W2899784297 abstract "BACKGROUND: Data are sparse on treatment of chronic hepatitis C virus (HCV) in cancer patients. We evaluated the efficacy and safety of sofosbuvir-based therapy (SOFBT) in cancer patients. METHODS: Patients treated with SOFBT at our center during 2014–2017 were included in a prospective observational study. Efficacy [sustained virologic response at 12 weeks after the end of treatment (SVR12)], cancer-related outcomes and adverse events (AEs) were assessed. RESULTS: We included 153 patients. Most were men (109; 71%), white (92; 60%), non-cirrhotic (105; 69%), and with HCV genotype 1 (110; 72%). The most common cancers were hepatocellular carcinoma (HCC) (27; 18%) and multiple myeloma (14; 9%). The overall SVR12 rate was 91% (128/141). SVR12 was 100% in patients treated with ledipasvir/sofosbuvir for 8 weeks. Of the 32 patients initially excluded from cancer clinical trials because of HCV, 27 (84%) were granted cancer therapy access after starting SOFBT. Six patients with indolent non-Hodgkin’s lymphoma (NHL) received SOFBT without cancer treatment. Two achieved complete remission, one had partial remission, and two had stable cancer. Within 6 months after SOFBT, 5% (6/121) of patients in remission or with stable cancer, had progression or recurrence (two with HCC and one each with esophageal cancer, cholangiocarcinoma, NHL, and tonsillar cancer). No de novo HCCs occurred. AEs were most commonly grade 1–2 (90%). CONCLUSIONS: SOFBT in HCV-infected cancer patients is effective and safe, may permit access to investigational cancer therapy expanding treatment options, may induce remission of NHL, and may be used for 8 weeks." @default.
• W2899784297 created "2018-11-16" @default.
• W2899784297 creator A5000176215 @default.
• W2899784297 creator A5005436649 @default.
• W2899784297 creator A5007730121 @default.
• W2899784297 creator A5011158737 @default.
• W2899784297 creator A5016365495 @default.
• W2899784297 creator A5017742999 @default.
• W2899784297 creator A5021444537 @default.
• W2899784297 creator A5033841614 @default.
• W2899784297 creator A5038343437 @default.
• W2899784297 creator A5039599664 @default.
• W2899784297 creator A5046065062 @default.
• W2899784297 creator A5055182697 @default.
• W2899784297 creator A5070455368 @default.
• W2899784297 creator A5089608031 @default.
• W2899784297 date "2018-11-08" @default.
• W2899784297 modified "2023-09-25" @default.
• W2899784297 title "Sofosbuvir-Based Therapy in Hepatitis C Virus-Infected Cancer Patients: A Prospective Observational Study" @default.
• W2899784297 cites W1903197017 @default.
• W2899784297 cites W2011345683 @default.
• W2899784297 cites W2019607817 @default.
• W2899784297 cites W2042108891 @default.
• W2899784297 cites W2092646281 @default.
• W2899784297 cites W2097405564 @default.
• W2899784297 cites W2133201432 @default.
• W2899784297 cites W2135778126 @default.
• W2899784297 cites W2136034282 @default.
• W2899784297 cites W2150652264 @default.
• W2899784297 cites W2222306685 @default.
• W2899784297 cites W2320330796 @default.
• W2899784297 cites W2339375057 @default.
• W2899784297 cites W2342648336 @default.
• W2899784297 cites W2420900831 @default.
• W2899784297 cites W2465057604 @default.
• W2899784297 cites W2467784130 @default.
• W2899784297 cites W2472882577 @default.
• W2899784297 cites W2473720327 @default.
• W2899784297 cites W2504685419 @default.
• W2899784297 cites W2507376318 @default.
• W2899784297 cites W2509211555 @default.
• W2899784297 cites W2520293475 @default.
• W2899784297 cites W2520394128 @default.
• W2899784297 cites W2531439807 @default.
• W2899784297 cites W2562480176 @default.
• W2899784297 cites W2593387920 @default.
• W2899784297 cites W2613337995 @default.
• W2899784297 cites W2617500612 @default.
• W2899784297 cites W2732983362 @default.
• W2899784297 cites W2734474168 @default.
• W2899784297 cites W2752566336 @default.
• W2899784297 cites W2761072514 @default.
• W2899784297 cites W2766364958 @default.
• W2899784297 cites W2800481490 @default.
• W2899784297 doi "https://doi.org/10.1038/s41395-018-0383-2" @default.
• W2899784297 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30410039" @default.
• W2899784297 hasPublicationYear "2018" @default.
• W2899784297 type Work @default.
• W2899784297 sameAs 2899784297 @default.
• W2899784297 citedByCount "15" @default.
• W2899784297 countsByYear W28997842972019 @default.
• W2899784297 countsByYear W28997842972020 @default.
• W2899784297 countsByYear W28997842972021 @default.
• W2899784297 countsByYear W28997842972022 @default.
• W2899784297 countsByYear W28997842972023 @default.
• W2899784297 crossrefType "journal-article" @default.
• W2899784297 hasAuthorship W2899784297A5000176215 @default.
• W2899784297 hasAuthorship W2899784297A5005436649 @default.
• W2899784297 hasAuthorship W2899784297A5007730121 @default.
• W2899784297 hasAuthorship W2899784297A5011158737 @default.
• W2899784297 hasAuthorship W2899784297A5016365495 @default.
• W2899784297 hasAuthorship W2899784297A5017742999 @default.
• W2899784297 hasAuthorship W2899784297A5021444537 @default.
• W2899784297 hasAuthorship W2899784297A5033841614 @default.
• W2899784297 hasAuthorship W2899784297A5038343437 @default.
• W2899784297 hasAuthorship W2899784297A5039599664 @default.
• W2899784297 hasAuthorship W2899784297A5046065062 @default.
• W2899784297 hasAuthorship W2899784297A5055182697 @default.
• W2899784297 hasAuthorship W2899784297A5070455368 @default.
• W2899784297 hasAuthorship W2899784297A5089608031 @default.
• W2899784297 hasConcept C121608353 @default.
• W2899784297 hasConcept C126322002 @default.
• W2899784297 hasConcept C143998085 @default.
• W2899784297 hasConcept C197934379 @default.
• W2899784297 hasConcept C203014093 @default.
• W2899784297 hasConcept C2522874641 @default.
• W2899784297 hasConcept C2775999097 @default.
• W2899784297 hasConcept C2776231280 @default.
• W2899784297 hasConcept C2776408679 @default.
• W2899784297 hasConcept C2776455275 @default.
• W2899784297 hasConcept C2778019345 @default.
• W2899784297 hasConcept C2778390639 @default.
• W2899784297 hasConcept C2780040827 @default.
• W2899784297 hasConcept C71924100 @default.
• W2899784297 hasConcept C90924648 @default.
• W2899784297 hasConceptScore W2899784297C121608353 @default.
• W2899784297 hasConceptScore W2899784297C126322002 @default.
• W2899784297 hasConceptScore W2899784297C143998085 @default.

• next