Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899790811> ?p ?o ?g. }
- W2899790811 endingPage "176" @default.
- W2899790811 startingPage "169" @default.
- W2899790811 abstract "Although many drugs/treatments are now available for most diseases, too often, resistance to these treatments impedes complete therapeutic success. Acquired resistance is a major problem in many pathologies but it is an acute one in cancers and infections. This is probably because these diseases often require long durations of treatment, which ascribe to the selection of resistant cells. However, the actual mechanisms implicated in the selection process are still under debate. It is becoming increasingly clear that resistance is associated with the heterogeneity of cancer cells or micro-organisms and that multiple mechanisms underlie the emergence of drug-resistant subpopulations. Recently, it has been suggested that a subpopulation of drug tolerant cells present in cancer populations and called persisters play a major role in this resistance. Recent studies have shown that microorganisms share similar properties. Still, how persister/tolerant cells intervene in the development of resistance is not completely elucidated but seems to be related to epigenetic changes in treated cells and the capacity of persisters to modulate and/or highjack their microenvironment. Due to the complexity of this process, the input from mathematicians, as well as new methods of bioinformatics and statistics, is necessary to fully comprehend the acquisition of resistance/tolerance deriving from and leading to the heterogeneous cell populations. The present review will give a brief overview of the most recent data available on drug tolerant cells in cancers and their similarities with microorganisms." @default.
- W2899790811 created "2018-11-16" @default.
- W2899790811 creator A5019382716 @default.
- W2899790811 creator A5027603422 @default.
- W2899790811 creator A5028466138 @default.
- W2899790811 creator A5036886359 @default.
- W2899790811 creator A5054297446 @default.
- W2899790811 creator A5071399321 @default.
- W2899790811 creator A5077898438 @default.
- W2899790811 creator A5087248752 @default.
- W2899790811 date "2019-04-01" @default.
- W2899790811 modified "2023-10-16" @default.
- W2899790811 title "Dormant, quiescent, tolerant and persister cells: Four synonyms for the same target in cancer" @default.
- W2899790811 cites W1572656384 @default.
- W2899790811 cites W1591674690 @default.
- W2899790811 cites W177263136 @default.
- W2899790811 cites W1823603681 @default.
- W2899790811 cites W1834592195 @default.
- W2899790811 cites W1864373769 @default.
- W2899790811 cites W1900398835 @default.
- W2899790811 cites W1969179300 @default.
- W2899790811 cites W1977138279 @default.
- W2899790811 cites W1987012261 @default.
- W2899790811 cites W1987835971 @default.
- W2899790811 cites W1990876362 @default.
- W2899790811 cites W2007614382 @default.
- W2899790811 cites W2008878539 @default.
- W2899790811 cites W2023560061 @default.
- W2899790811 cites W2030683290 @default.
- W2899790811 cites W2033363278 @default.
- W2899790811 cites W2034744133 @default.
- W2899790811 cites W2042619042 @default.
- W2899790811 cites W2043201642 @default.
- W2899790811 cites W2044442379 @default.
- W2899790811 cites W2064489931 @default.
- W2899790811 cites W2066522128 @default.
- W2899790811 cites W2073302269 @default.
- W2899790811 cites W2077553663 @default.
- W2899790811 cites W2080034938 @default.
- W2899790811 cites W2080364804 @default.
- W2899790811 cites W2082373777 @default.
- W2899790811 cites W2083987547 @default.
- W2899790811 cites W2085139253 @default.
- W2899790811 cites W2091997954 @default.
- W2899790811 cites W2098018866 @default.
- W2899790811 cites W2101818435 @default.
- W2899790811 cites W2101937561 @default.
- W2899790811 cites W2110376710 @default.
- W2899790811 cites W2112933240 @default.
- W2899790811 cites W2117098158 @default.
- W2899790811 cites W2121581196 @default.
- W2899790811 cites W2123558100 @default.
- W2899790811 cites W2127817798 @default.
- W2899790811 cites W2143879648 @default.
- W2899790811 cites W2149053153 @default.
- W2899790811 cites W2155542819 @default.
- W2899790811 cites W2160425962 @default.
- W2899790811 cites W2161186493 @default.
- W2899790811 cites W2166576553 @default.
- W2899790811 cites W2171298396 @default.
- W2899790811 cites W2179429273 @default.
- W2899790811 cites W2189531780 @default.
- W2899790811 cites W2275679174 @default.
- W2899790811 cites W2297970061 @default.
- W2899790811 cites W2344402255 @default.
- W2899790811 cites W2345787662 @default.
- W2899790811 cites W2461078780 @default.
- W2899790811 cites W2508793696 @default.
- W2899790811 cites W2510922180 @default.
- W2899790811 cites W2522829580 @default.
- W2899790811 cites W2523245974 @default.
- W2899790811 cites W2528481396 @default.
- W2899790811 cites W2551783204 @default.
- W2899790811 cites W2553568946 @default.
- W2899790811 cites W2560396365 @default.
- W2899790811 cites W2582245087 @default.
- W2899790811 cites W2591765352 @default.
- W2899790811 cites W2595145824 @default.
- W2899790811 cites W2599172995 @default.
- W2899790811 cites W2602907179 @default.
- W2899790811 cites W2610504281 @default.
- W2899790811 cites W2612653435 @default.
- W2899790811 cites W2620525720 @default.
- W2899790811 cites W2737684804 @default.
- W2899790811 cites W2745178135 @default.
- W2899790811 cites W2756267081 @default.
- W2899790811 cites W2762459475 @default.
- W2899790811 cites W2767055857 @default.
- W2899790811 cites W2768570399 @default.
- W2899790811 cites W2775101460 @default.
- W2899790811 cites W2778942513 @default.
- W2899790811 cites W2778954596 @default.
- W2899790811 cites W2790091979 @default.
- W2899790811 cites W2792495697 @default.
- W2899790811 cites W2793989068 @default.
- W2899790811 cites W2796472927 @default.
- W2899790811 cites W2801923213 @default.
- W2899790811 cites W2803097081 @default.