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• W2899832990 abstract "Monitoring the level of exchangeable copper (CuEXC) and ceruloplasmin (Cp) in serum is of great significance for Wilson’s disease (WD). In this work, a facile one-step competitive immunoassay for rapid and simultaneous detection of CuEXC and Cp has been developed based on antigens coated magnetic nanoparticles (immuno-MNPs) and antibodies functionalized quantum dots (QDs-Abs). Just by mixing immuno-MNPs, with diluted serum and QDs-Abs together, the antigens on immuno-MNPs compete with the target in serum and bind to QDs-Abs, thereby causing the changes in fluorescence intensity of QDs. Under selected conditions, this one-step method exhibited excellent precision and selectivity with the measured limit of detection of 0.2 nM and 7.0 μg/L for CuEXC and Cp, respectively. Most importantly, this method was successfully applied to detect CuEXC and Cp without the usual time-consuming pretreatment. The results showed no significant difference (P>0.01) from those of ICP-AES and ELISA; moreover, CuEXC significantly decreased to a normal level after the treatment of preliminarily diagnosed WD patients, while the changes of Cp level is not significant (P > 0.01). Therefore, the proposed one-step competitive immunoassay has great potential applications in the rapid laboratory diagnosis of WD with distinct advantages over the existing methods in terms of multi-target, accuracy, facile, fast and cost-effectiveness." @default.
• W2899832990 created "2018-11-16" @default.
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• W2899832990 date "2019-02-01" @default.
• W2899832990 modified "2023-10-18" @default.
• W2899832990 title "Rapid laboratory diagnosis of Wilson’s disease: One-step simultaneous detection of exchangeable copper and ceruloplasmin in serum based on nanotechnology" @default.
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• W2899832990 doi "https://doi.org/10.1016/j.snb.2018.11.012" @default.
• W2899832990 hasPublicationYear "2019" @default.
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