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- W2899838052 abstract "In eukaryotic cells, gene expression is highly regulated at many layers. Nascent RNA molecules are assembled into ribonucleoprotein complexes that are then released into the nucleoplasmic milieu and transferred to the nuclear pore complex for nuclear export. RNAs are then either translated or transported to the cellular periphery. Emerging evidence indicates that RNA binding proteins play an essential role throughout RNA biogenesis, from the gene to polyribosomes. However, the sorting mechanisms that regulate whether an RNA molecule is immediately translated or sent to specialized locations for translation are unclear. This question is highly relevant during development and differentiation when cells acquire a specific identity. Here, we focus on the RNA binding properties of heterogeneous nuclear ribonucleoproteins (hnRNPs) and how these mechanisms are believed to play an essential role in RNA trafficking in polarized cells. Further, by focusing on the specific hnRNP protein hnRNPab/CBF-A and its naturally occurring isoforms, we propose a model on how hnRNP proteins are capable of regulating gene expression both spatially and temporally throughout the RNA biogenesis pathway, impacting both healthy and diseased cells." @default.
- W2899838052 created "2018-11-16" @default.
- W2899838052 creator A5073825779 @default.
- W2899838052 creator A5084691908 @default.
- W2899838052 date "2018-11-06" @default.
- W2899838052 modified "2023-10-15" @default.
- W2899838052 title "Sorting mRNA Molecules for Cytoplasmic Transport and Localization" @default.
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- W2899838052 doi "https://doi.org/10.3389/fgene.2018.00510" @default.
- W2899838052 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6232293" @default.
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- W2899838052 hasPublicationYear "2018" @default.
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