Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899864694> ?p ?o ?g. }
- W2899864694 endingPage "17" @default.
- W2899864694 startingPage "9" @default.
- W2899864694 abstract "The renin angiotensin-aldosterone system (RAAS) and lipoxins (LXs) have similar roles in many processes. We previously reported that BML-111, a Lipoxin receptor agonist, inhibited chronic injury hepatic fibrosis by regulating RAAS, but whether LXs are involved in BML-111-mediated protection from acute injury is unclear still.We established models of acute liver/lung injury and confirmed them with histopathology and myeloperoxidase (MPO) measurements. BML-111, a lipoxin receptor agonist, was applied to mimic the effects of LXs. The contents and activities of angiotensin converting enzyme(ACE) and angiotensinconverting enzyme 2 (ACE2) were measured through ELISA and activity assay kits respectively. Angiotensin II (AngII), angiotensin-(1-7) (Ang-1-7), AngII type 1 receptor (AT1R), and Mas receptor were quantified with ELISA and Western blot.Models of acute injury were established successfully and BML-111 protected LPS-induced acute lung injury and LPS/D-GalN-induced acute liver injury. BML-111 repressed the activity of ACE, but increased the activity of ACE2. BML-111 decreased the expression levels of ACE, AngII, and AT1R, meanwhile increased the levels of ACE2, Ang-(1-7), and Mas. Furthermore, BOC-2, an inhibitor of lipoxin receptor, reversed all the effects.BML-111 could protect against acute injury via regulation RAAS." @default.
- W2899864694 created "2018-11-16" @default.
- W2899864694 creator A5000813870 @default.
- W2899864694 creator A5002098147 @default.
- W2899864694 creator A5007057624 @default.
- W2899864694 creator A5053469380 @default.
- W2899864694 creator A5070659245 @default.
- W2899864694 creator A5072261631 @default.
- W2899864694 date "2019-02-01" @default.
- W2899864694 modified "2023-09-27" @default.
- W2899864694 title "BML-111, a lipoxin receptor agonist, protects against acute injury via regulating the renin angiotensin-aldosterone system" @default.
- W2899864694 cites W1118162442 @default.
- W2899864694 cites W1419244406 @default.
- W2899864694 cites W1571096997 @default.
- W2899864694 cites W1821554906 @default.
- W2899864694 cites W1877587007 @default.
- W2899864694 cites W1966267852 @default.
- W2899864694 cites W1967379906 @default.
- W2899864694 cites W1975531685 @default.
- W2899864694 cites W1975770623 @default.
- W2899864694 cites W1976894129 @default.
- W2899864694 cites W1985036969 @default.
- W2899864694 cites W1986639720 @default.
- W2899864694 cites W1989162473 @default.
- W2899864694 cites W1990214228 @default.
- W2899864694 cites W1998377876 @default.
- W2899864694 cites W2005382767 @default.
- W2899864694 cites W2014161419 @default.
- W2899864694 cites W2017459289 @default.
- W2899864694 cites W2030335039 @default.
- W2899864694 cites W2039986293 @default.
- W2899864694 cites W2041445241 @default.
- W2899864694 cites W2050908044 @default.
- W2899864694 cites W2052182309 @default.
- W2899864694 cites W2060256297 @default.
- W2899864694 cites W2064547101 @default.
- W2899864694 cites W2068167523 @default.
- W2899864694 cites W2069168994 @default.
- W2899864694 cites W2070459088 @default.
- W2899864694 cites W2075340072 @default.
- W2899864694 cites W2076522158 @default.
- W2899864694 cites W2082591981 @default.
- W2899864694 cites W2082943727 @default.
- W2899864694 cites W2087264343 @default.
- W2899864694 cites W2104541229 @default.
- W2899864694 cites W2106605319 @default.
- W2899864694 cites W2109571332 @default.
- W2899864694 cites W2111290043 @default.
- W2899864694 cites W2133075832 @default.
- W2899864694 cites W2138043907 @default.
- W2899864694 cites W2145217096 @default.
- W2899864694 cites W2155014088 @default.
- W2899864694 cites W2155045770 @default.
- W2899864694 cites W2156835140 @default.
- W2899864694 cites W2159766146 @default.
- W2899864694 cites W2161119132 @default.
- W2899864694 cites W2161399617 @default.
- W2899864694 cites W2165677092 @default.
- W2899864694 cites W2171077374 @default.
- W2899864694 cites W2177645820 @default.
- W2899864694 cites W2323387726 @default.
- W2899864694 cites W2341413642 @default.
- W2899864694 cites W2460641766 @default.
- W2899864694 cites W2518497722 @default.
- W2899864694 cites W2522948738 @default.
- W2899864694 cites W2746094640 @default.
- W2899864694 doi "https://doi.org/10.1016/j.prostaglandins.2018.11.001" @default.
- W2899864694 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30412790" @default.
- W2899864694 hasPublicationYear "2019" @default.
- W2899864694 type Work @default.
- W2899864694 sameAs 2899864694 @default.
- W2899864694 citedByCount "9" @default.
- W2899864694 countsByYear W28998646942020 @default.
- W2899864694 countsByYear W28998646942021 @default.
- W2899864694 countsByYear W28998646942022 @default.
- W2899864694 countsByYear W28998646942023 @default.
- W2899864694 crossrefType "journal-article" @default.
- W2899864694 hasAuthorship W2899864694A5000813870 @default.
- W2899864694 hasAuthorship W2899864694A5002098147 @default.
- W2899864694 hasAuthorship W2899864694A5007057624 @default.
- W2899864694 hasAuthorship W2899864694A5053469380 @default.
- W2899864694 hasAuthorship W2899864694A5070659245 @default.
- W2899864694 hasAuthorship W2899864694A5072261631 @default.
- W2899864694 hasConcept C126322002 @default.
- W2899864694 hasConcept C134018914 @default.
- W2899864694 hasConcept C170493617 @default.
- W2899864694 hasConcept C185592680 @default.
- W2899864694 hasConcept C198710026 @default.
- W2899864694 hasConcept C203565725 @default.
- W2899864694 hasConcept C27016395 @default.
- W2899864694 hasConcept C2775946041 @default.
- W2899864694 hasConcept C2776914184 @default.
- W2899864694 hasConcept C2778525890 @default.
- W2899864694 hasConcept C2778938600 @default.
- W2899864694 hasConcept C2779134260 @default.
- W2899864694 hasConcept C2780415110 @default.
- W2899864694 hasConcept C2908929049 @default.
- W2899864694 hasConcept C3008058167 @default.