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• W2899871244 endingPage "3466" @default.
• W2899871244 startingPage "3466" @default.
• W2899871244 abstract "Autophagy is an intracellular degradative process that occurs under several stressful conditions, including organelle damage, the presence of abnormal proteins, and nutrient deprivation. The mechanism of autophagy initiates the formation of autophagosomes that capture degraded components and then fuse with lysosomes to recycle these components. The modulation of autophagy plays dual roles in tumor suppression and promotion in many cancers. In addition, autophagy regulates the properties of cancer stem-cells by contributing to the maintenance of stemness, the induction of recurrence, and the development of resistance to anticancer reagents. Although some autophagy modulators, such as rapamycin and chloroquine, are used to regulate autophagy in anticancer therapy, since this process also plays roles in both tumor suppression and promotion, the precise mechanism of autophagy in cancer requires further study. In this review, we will summarize the mechanism of autophagy under stressful conditions and its roles in tumor suppression and promotion in cancer and in cancer stem-cells. Furthermore, we discuss how autophagy is a promising potential therapeutic target in cancer treatment." @default.
• W2899871244 created "2018-11-16" @default.
• W2899871244 creator A5076209952 @default.
• W2899871244 creator A5086392170 @default.
• W2899871244 date "2018-11-05" @default.
• W2899871244 modified "2023-10-17" @default.
• W2899871244 title "The Roles of Autophagy in Cancer" @default.
• W2899871244 cites W1019836896 @default.
• W2899871244 cites W1514420217 @default.
• W2899871244 cites W1523693806 @default.
• W2899871244 cites W1560257487 @default.
• W2899871244 cites W1566724399 @default.
• W2899871244 cites W1592095850 @default.
• W2899871244 cites W1638254043 @default.
• W2899871244 cites W1678795445 @default.
• W2899871244 cites W1784425676 @default.
• W2899871244 cites W1799143857 @default.
• W2899871244 cites W1839957747 @default.
• W2899871244 cites W1964081206 @default.
• W2899871244 cites W1965766554 @default.
• W2899871244 cites W1968684554 @default.
• W2899871244 cites W1969057487 @default.
• W2899871244 cites W1970637701 @default.
• W2899871244 cites W1971495943 @default.
• W2899871244 cites W1974735562 @default.
• W2899871244 cites W1976246361 @default.
• W2899871244 cites W1976921001 @default.
• W2899871244 cites W1977079962 @default.
• W2899871244 cites W1977767269 @default.
• W2899871244 cites W1978917500 @default.
• W2899871244 cites W1979783084 @default.
• W2899871244 cites W1982408819 @default.
• W2899871244 cites W1982513324 @default.
• W2899871244 cites W1982809908 @default.
• W2899871244 cites W1983057100 @default.
• W2899871244 cites W1983788491 @default.
• W2899871244 cites W1984209860 @default.
• W2899871244 cites W1986810195 @default.
• W2899871244 cites W1987769185 @default.
• W2899871244 cites W1988475811 @default.
• W2899871244 cites W1991903498 @default.
• W2899871244 cites W1992480030 @default.
• W2899871244 cites W1992659717 @default.
• W2899871244 cites W1994084445 @default.
• W2899871244 cites W1994993231 @default.
• W2899871244 cites W1996362044 @default.
• W2899871244 cites W1997888372 @default.
• W2899871244 cites W2001591494 @default.
• W2899871244 cites W2004774286 @default.
• W2899871244 cites W2006986876 @default.
• W2899871244 cites W2009284352 @default.
• W2899871244 cites W2013383578 @default.
• W2899871244 cites W2015831734 @default.
• W2899871244 cites W2019816136 @default.
• W2899871244 cites W2021828703 @default.
• W2899871244 cites W2023338943 @default.
• W2899871244 cites W2023427658 @default.
• W2899871244 cites W2024650854 @default.
• W2899871244 cites W2026893014 @default.
• W2899871244 cites W2031540002 @default.
• W2899871244 cites W2035707754 @default.
• W2899871244 cites W2038882533 @default.
• W2899871244 cites W2039403501 @default.
• W2899871244 cites W2039607936 @default.
• W2899871244 cites W2040533720 @default.
• W2899871244 cites W2040778960 @default.
• W2899871244 cites W2042198997 @default.
• W2899871244 cites W2043028930 @default.
• W2899871244 cites W2045122835 @default.
• W2899871244 cites W2049953895 @default.
• W2899871244 cites W2052388933 @default.
• W2899871244 cites W2052618262 @default.
• W2899871244 cites W2055811314 @default.
• W2899871244 cites W2056852821 @default.
• W2899871244 cites W2059036087 @default.
• W2899871244 cites W2059388879 @default.
• W2899871244 cites W2061772840 @default.
• W2899871244 cites W2062056725 @default.
• W2899871244 cites W206414211 @default.
• W2899871244 cites W2064741210 @default.
• W2899871244 cites W2066379425 @default.
• W2899871244 cites W2066800765 @default.
• W2899871244 cites W2068136919 @default.
• W2899871244 cites W2071732560 @default.
• W2899871244 cites W2073762029 @default.
• W2899871244 cites W2077757969 @default.
• W2899871244 cites W2078184757 @default.
• W2899871244 cites W2078768940 @default.
• W2899871244 cites W2079355772 @default.
• W2899871244 cites W2081057817 @default.
• W2899871244 cites W2083440174 @default.
• W2899871244 cites W2083919459 @default.
• W2899871244 cites W2084350287 @default.
• W2899871244 cites W2085586604 @default.
• W2899871244 cites W2086528604 @default.
• W2899871244 cites W2088963481 @default.
• W2899871244 cites W2089230333 @default.
• W2899871244 cites W2089848941 @default.

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