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- W2899875330 abstract "Neuroscience encompasses the investigation of brain function across multiple spatiotemporal scales. Yet, most research is confined to one spatiotemporal milieu limiting the integration of knowledge across scales. Here we describe an imaging and analytic approach that spans spatiotemporal scales by combining simultaneous wide field mesoscopic 1-photon Ca 2+ imaging and functional magnetic resonance imaging (fMRI) at 11.7T. Given the confined space within the magnet, that metal is prohibited, and the unique/conflicting needs of each methodology, these techniques have never before been combined. In addition to describing the new hardware and software, we present evoked and spontaneous activity measurements made in lightly anesthetized animals. We have three findings: (1) for both evoked and spontaneous activity the magnitude of the Ca 2+ and fMRI signals show correspondence, (2) connectivity matrices derived from Ca 2+ and fMRI measurements are stable throughout an imaging session, and (3) there is correspondence between Ca 2+ and fMRI spontaneous activity patterns." @default.
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- W2899875330 date "2018-11-06" @default.
- W2899875330 modified "2023-09-26" @default.
- W2899875330 title "Spanning spatiotemporal scales with simultaneous mesoscopic Ca2+ imaging and functional MRI" @default.
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