FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899897229> ?p ?o ?g. }

• W2899897229 endingPage "195" @default.
• W2899897229 startingPage "187" @default.
• W2899897229 abstract "Attention deficit hyperactivity disorder (ADHD) has a prevalence of 7.5% in school-age children in Taiwan. A number of ADHD patients start taking medications in elementary school and continue their treatment until they are in college or adulthood. Methylphenidate is the most frequently used medication prescribed for ADHD treatment. The influence of long-term treatment of methylphenidate on neuro-development, especially dopaminergic neurons, in rats would be explored. This study investigated the impact of long-term treatment of methylphenidate on different neurons. Rats aged 1 month were divided into three groups: Normal group receiving only sucrose solution, Low-dose group receiving 2 mg/kg methylphenidate, and High-dose group receiving 10 mg/kg methylphenidate; for each group, the drug was administrated twice per day. After 7 months of the treatment period, then the alterations in number of norepinephrine, serotonergic, cholinergic and dopaminergic neurons were quantified. The number of dopaminergic neurons in the substantia nigra (SN), the serotonergic neurons in the dorsal raphe nucleus, and the cholinergic neurons in the tegmental nucleus significantly decreased as compared with Normal group, whereas the noradrenergic neurons in the locus coeruleus substantially increased. The whole-cell recording was made from dopaminergic neurons residing in the SN for examination of their firing activity. The recorded dopaminergic neurons in SN were categorized into slow and fast firing using 10 Hz as a classified index. The results displayed that the ratio of dopaminergic neurons with fast firing in the High-dose group was less as compared with those in the Normal and the Low-dose group. Furthermore, the amplitude of action potential of the dopaminergic neurons with slow firing was higher in the High-dose group than those in the Normal and Low-dose groups. The firing behavior of dopaminergic neurons and dopamine concentration in the brain is affected by the long-term challenge of methylphenidate." @default.
• W2899897229 created "2018-11-16" @default.
• W2899897229 creator A5001375220 @default.
• W2899897229 creator A5019393845 @default.
• W2899897229 creator A5021059942 @default.
• W2899897229 creator A5039772674 @default.
• W2899897229 date "2019-01-01" @default.
• W2899897229 modified "2023-10-14" @default.
• W2899897229 title "Long-term challenge of methylphenidate changes the neuronal population and membrane property of dopaminergic neuron in rats" @default.
• W2899897229 cites W1577405291 @default.
• W2899897229 cites W1709926499 @default.
• W2899897229 cites W1840984304 @default.
• W2899897229 cites W1896466592 @default.
• W2899897229 cites W1966144887 @default.
• W2899897229 cites W1973681283 @default.
• W2899897229 cites W1977634040 @default.
• W2899897229 cites W1980460020 @default.
• W2899897229 cites W1981896177 @default.
• W2899897229 cites W1981961774 @default.
• W2899897229 cites W1995370297 @default.
• W2899897229 cites W1995992264 @default.
• W2899897229 cites W2002632542 @default.
• W2899897229 cites W2007945499 @default.
• W2899897229 cites W2014488168 @default.
• W2899897229 cites W2018718529 @default.
• W2899897229 cites W2021075309 @default.
• W2899897229 cites W2043537094 @default.
• W2899897229 cites W2045558460 @default.
• W2899897229 cites W2048752288 @default.
• W2899897229 cites W2062612291 @default.
• W2899897229 cites W2077461364 @default.
• W2899897229 cites W2081767867 @default.
• W2899897229 cites W2082738856 @default.
• W2899897229 cites W2083583425 @default.
• W2899897229 cites W2084103591 @default.
• W2899897229 cites W2085060924 @default.
• W2899897229 cites W2085930600 @default.
• W2899897229 cites W2093024075 @default.
• W2899897229 cites W2095782630 @default.
• W2899897229 cites W2098139332 @default.
• W2899897229 cites W2098677721 @default.
• W2899897229 cites W2102478882 @default.
• W2899897229 cites W2113895006 @default.
• W2899897229 cites W2115083032 @default.
• W2899897229 cites W2118865186 @default.
• W2899897229 cites W2119199396 @default.
• W2899897229 cites W2133711068 @default.
• W2899897229 cites W2138001941 @default.
• W2899897229 cites W2140513029 @default.
• W2899897229 cites W2142011448 @default.
• W2899897229 cites W2163407153 @default.
• W2899897229 cites W2165076523 @default.
• W2899897229 cites W2165350357 @default.
• W2899897229 cites W2191245370 @default.
• W2899897229 cites W2331913791 @default.
• W2899897229 cites W2405138604 @default.
• W2899897229 cites W2475198594 @default.
• W2899897229 cites W2513677007 @default.
• W2899897229 cites W2555288385 @default.
• W2899897229 cites W2755809883 @default.
• W2899897229 cites W79926215 @default.
• W2899897229 doi "https://doi.org/10.1016/j.neuint.2018.11.001" @default.
• W2899897229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30423424" @default.
• W2899897229 hasPublicationYear "2019" @default.
• W2899897229 type Work @default.
• W2899897229 sameAs 2899897229 @default.
• W2899897229 citedByCount "3" @default.
• W2899897229 countsByYear W28998972292021 @default.
• W2899897229 crossrefType "journal-article" @default.
• W2899897229 hasAuthorship W2899897229A5001375220 @default.
• W2899897229 hasAuthorship W2899897229A5019393845 @default.
• W2899897229 hasAuthorship W2899897229A5021059942 @default.
• W2899897229 hasAuthorship W2899897229A5039772674 @default.
• W2899897229 hasConcept C104966671 @default.
• W2899897229 hasConcept C118552586 @default.
• W2899897229 hasConcept C126322002 @default.
• W2899897229 hasConcept C134018914 @default.
• W2899897229 hasConcept C137183658 @default.
• W2899897229 hasConcept C15744967 @default.
• W2899897229 hasConcept C169760540 @default.
• W2899897229 hasConcept C170493617 @default.
• W2899897229 hasConcept C22885893 @default.
• W2899897229 hasConcept C2775864247 @default.
• W2899897229 hasConcept C2777112843 @default.
• W2899897229 hasConcept C2778468602 @default.
• W2899897229 hasConcept C2778794669 @default.
• W2899897229 hasConcept C2780723820 @default.
• W2899897229 hasConcept C2780783007 @default.
• W2899897229 hasConcept C2780938664 @default.
• W2899897229 hasConcept C32610206 @default.
• W2899897229 hasConcept C37000724 @default.
• W2899897229 hasConcept C513476851 @default.
• W2899897229 hasConcept C71924100 @default.
• W2899897229 hasConceptScore W2899897229C104966671 @default.
• W2899897229 hasConceptScore W2899897229C118552586 @default.
• W2899897229 hasConceptScore W2899897229C126322002 @default.
• W2899897229 hasConceptScore W2899897229C134018914 @default.
• W2899897229 hasConceptScore W2899897229C137183658 @default.

• next