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• W2899931953 abstract "Journal of Paediatrics and Child HealthVolume 50, Issue 10 p. 836-836 Heads UpFree Access Risk of subsequent attention deficit-hyperactivity disorder in children with febrile seizures First published: 06 October 2014 https://doi.org/10.1111/jpc.12723 edited by Craig Mellis (craig.mellis@sydney.edu.au) AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat The recent article by Ku et al. published in Archives of Disease in Childhood challenges the long-held paradigm that febrile seizures are a benign condition of childhood.1 The authors' avail of a population-based research database with 99.9% national coverage in Taiwan and employ a robust statistical model to demonstrate a correlation between the frequency of febrile seizures in childhood and the subsequent development of attention-deficit/hyperactivity disorder. There is, however, a failure to acknowledge the limitations of the study leading to a final conclusion unsupported by the data presented. The key limitations of this study are the assumption that a diagnosis of ADHD would be as clearly defined as a diagnosis of ischemic stroke for which the database was previously validated, that matching for age, sex, urbanisation and occupation was sufficient to equalise the group with an exposure of febrile seizures and that the prevalence of ADHD was static over the time period of the study (a key assumption when employing Cox's proportional hazard method). Key clinical factors that were ignored were the age and complexity of the febrile seizures in question. The discussion failed to place this work in the context of the current literature and was very haphazard in its attempts to identify a plausible biologic mechanism for the observed correlation. The data presented in this study raise important and interesting questions for paediatricians, researchers and parents; however, the results of this study do not support consideration of a change in approach or management of febrile seizures at this time. Reference 1Ku Y-C et al. Arch. Dis. Child. 2014; 99: 322– 326. Reviewers: Bridget Freyne, bridget.freyne@rch.org.au; Lit Kim Chin, litkim.chin@rch.org.au; Caroline Kissane, Caroline.Kissane@rch.org.au; Tom Connell, tom.connell@rch.org.au Volume50, Issue10October 2014Pages 836-836 ReferencesRelatedInformation" @default.
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• W2899931953 title "Risk of subsequent attention deficit-hyperactivity disorder in children with febrile seizures" @default.
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