FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899946397> ?p ?o ?g. }

• W2899946397 endingPage "H182" @default.
• W2899946397 startingPage "H169" @default.
• W2899946397 abstract "Thoracic aortopathy, especially aneurysm, dissection, and rupture, is responsible for significant morbidity and mortality. Uncontrolled hypertension and aging are primary risk factors for such conditions, and they contribute to an increase in the mechanical stress on the wall and an increase in its structural vulnerability, respectively. Select genetic mutations also predispose to these lethal conditions, and the collection of known mutations suggests that dysfunctional mechanosensing and mechanoregulation of the extracellular matrix may contribute to pathogenesis and disease progression. In the absence of a well-accepted pharmacotherapy, nonsurgical treatments tend to focus on reducing the mechanical loading on the aorta, particularly via the use of antihypertensive medications and recommendations to avoid strenuous exercises such as weight lifting. In this brief review, we discuss the important effects of central artery stiffening on global hemodynamics and, in particular, on the increase in pulse pressure that acts on the proximal thoracic aorta. We consider Marfan syndrome as an illustrative aortopathy but discuss other conditions leading to thoracic aortic aneurysm and dissection. We highlight the importance of phenotyping the aorta biomechanically, not just clinically, and emphasize the utility of mouse models in elucidating molecular and mechanical mechanisms of disease. Notwithstanding the widely recognized role of central artery stiffening in driving end-organ disease, we suggest that there is similarly a need to consider its key role in thoracic aortopathy." @default.
• W2899946397 created "2018-11-16" @default.
• W2899946397 creator A5014180482 @default.
• W2899946397 creator A5036202065 @default.
• W2899946397 date "2019-01-01" @default.
• W2899946397 modified "2023-10-18" @default.
• W2899946397 title "Central artery stiffness and thoracic aortopathy" @default.
• W2899946397 cites W1834434186 @default.
• W2899946397 cites W1965791620 @default.
• W2899946397 cites W1967959058 @default.
• W2899946397 cites W1968109216 @default.
• W2899946397 cites W1976950008 @default.
• W2899946397 cites W1978976538 @default.
• W2899946397 cites W1980102404 @default.
• W2899946397 cites W1981737207 @default.
• W2899946397 cites W1984138395 @default.
• W2899946397 cites W1984335097 @default.
• W2899946397 cites W1994589849 @default.
• W2899946397 cites W1995088425 @default.
• W2899946397 cites W1995448925 @default.
• W2899946397 cites W2003248321 @default.
• W2899946397 cites W2007750258 @default.
• W2899946397 cites W2010473656 @default.
• W2899946397 cites W2011247521 @default.
• W2899946397 cites W2014171174 @default.
• W2899946397 cites W2014350811 @default.
• W2899946397 cites W2016193552 @default.
• W2899946397 cites W2027022294 @default.
• W2899946397 cites W2028507273 @default.
• W2899946397 cites W2037671352 @default.
• W2899946397 cites W2038878940 @default.
• W2899946397 cites W2039354854 @default.
• W2899946397 cites W2043359300 @default.
• W2899946397 cites W2043428292 @default.
• W2899946397 cites W2047367002 @default.
• W2899946397 cites W2050292374 @default.
• W2899946397 cites W2053715750 @default.
• W2899946397 cites W2055150247 @default.
• W2899946397 cites W2058738554 @default.
• W2899946397 cites W2060411911 @default.
• W2899946397 cites W2062042024 @default.
• W2899946397 cites W2063457183 @default.
• W2899946397 cites W2065853975 @default.
• W2899946397 cites W2067202687 @default.
• W2899946397 cites W2069703799 @default.
• W2899946397 cites W2070599153 @default.
• W2899946397 cites W2073614919 @default.
• W2899946397 cites W2078956491 @default.
• W2899946397 cites W2080113459 @default.
• W2899946397 cites W2080495541 @default.
• W2899946397 cites W2081189235 @default.
• W2899946397 cites W2097777092 @default.
• W2899946397 cites W2100637998 @default.
• W2899946397 cites W2101069563 @default.
• W2899946397 cites W2107675829 @default.
• W2899946397 cites W2107753444 @default.
• W2899946397 cites W2112123157 @default.
• W2899946397 cites W2112856272 @default.
• W2899946397 cites W2112943642 @default.
• W2899946397 cites W2113647338 @default.
• W2899946397 cites W2121822802 @default.
• W2899946397 cites W2122010708 @default.
• W2899946397 cites W2122595781 @default.
• W2899946397 cites W2123227231 @default.
• W2899946397 cites W2126736458 @default.
• W2899946397 cites W2128168840 @default.
• W2899946397 cites W2128455103 @default.
• W2899946397 cites W2129750803 @default.
• W2899946397 cites W2136350829 @default.
• W2899946397 cites W2138209376 @default.
• W2899946397 cites W2143286808 @default.
• W2899946397 cites W2146052423 @default.
• W2899946397 cites W2147543911 @default.
• W2899946397 cites W2153221979 @default.
• W2899946397 cites W2156559614 @default.
• W2899946397 cites W2157439044 @default.
• W2899946397 cites W2158121693 @default.
• W2899946397 cites W2165020996 @default.
• W2899946397 cites W2165971798 @default.
• W2899946397 cites W2168472925 @default.
• W2899946397 cites W2169754078 @default.
• W2899946397 cites W2171743973 @default.
• W2899946397 cites W2207060623 @default.
• W2899946397 cites W2214934803 @default.
• W2899946397 cites W2238998036 @default.
• W2899946397 cites W2259988342 @default.
• W2899946397 cites W2301329153 @default.
• W2899946397 cites W2465125755 @default.
• W2899946397 cites W2480924511 @default.
• W2899946397 cites W2501135183 @default.
• W2899946397 cites W2520068755 @default.
• W2899946397 cites W2524610039 @default.
• W2899946397 cites W2531581919 @default.
• W2899946397 cites W2567635463 @default.
• W2899946397 cites W2572871393 @default.
• W2899946397 cites W2592923626 @default.
• W2899946397 cites W2594216518 @default.
• W2899946397 cites W2594653562 @default.

• next