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• W2899962458 abstract "In hepatitis B virus (HBV)-related cirrhosis the antiviral therapy reduces portal hypertension (PH) and risk of hepatocellular carcinoma (HCC). This study assessed the prognostic role of LSPS Score (liver stiffness value X spleen diameter/platelet count) in predicting these goals in cirrhotic patients responsive to antiviral therapy.The correlation between LSPS, PH, esophageal varices (EVs) and HCC was evaluated in 121 cirrhotic patients treated with nucleos(t)ide analogues (NUCs). Sixty-one patients (50.4%) had PH at baseline. All were HBV DNA negative on-treatment. They were evaluated after a median of 8 years of therapy (1-17) for LSPS, PH, hepatic venous pressure gradient (HVPG), EVs and HCC.LSPS ≤0.62 and ≤1.4 identified patients without PH measured by HVPG (<6 mmHg, NPV=100%) and EVs (PPV 63.3%, NPV 93.7%), respectively. After antiviral therapy LSPS≤0.62 was detected in 51.3% of the patients (16.4% and 76.6% of subjects with and without PH at baseline, P<0.0001). HCC developed in 26 patients (21.5%, 2.6%-year) with a higher incidence in patients with LSPS>0.62 after antiviral therapy (36% vs. 7%, P<0.001). On multivariate analysis LSPS post-therapy and PH at baseline were the only independent predictors of HCC (OR: 1.18; 95% CI: 1.02-1.28, P=0.02 and OR: 1.70; 95% CI:1-2.86, P=0.04 respectively).LSPS is useful to identify patients with regression of PH and EVs, avoiding endoscopy. LSPS≤0.62 at baseline or due to antiviral therapy is associated with a lower risk of HCC. Early antiviral treatment is recommended in order to maintain or to induce LSPS≤0.62." @default.
• W2899962458 created "2018-11-16" @default.
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• W2899962458 date "2019-01-01" @default.
• W2899962458 modified "2023-09-26" @default.
• W2899962458 title "Liver stiffness-based model for portal hypertension and hepatocellular cancer risk in HBV responsive to antivirals" @default.
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• W2899962458 doi "https://doi.org/10.23736/s1121-421x.18.02534-5" @default.
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