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- W2899974179 abstract "Nanomaterials have been widely used as drug carriers in the biomedical field. However, most of them have limited application because of their poor biocompatibility, targeting, and degradability. Therefore, exploring and developing novel drug nanocarriers to overcome these problems has widely attracted attention. In this study, polydopamine-doped mesoporous silica nanocomposites (PMSNs) were controllably synthesized by a one-pot oil-water biphase stratification approach. PMSNs showed good biodegradability in degradation experiments and also proved to have superior biocompatibility toward hepatocellular carcinoma cells (HepG2) compared with mesoporous silica nanoparticles (MSNs). And PMSNs loaded doxorubicin (DOX) (PMSNs@DOX) exhibited a pH-responsive release effect. Meanwhile, compared with PMSNs@DOX, folic acid-modified PMSNs@DOX (PMSNs@DOX@FA) displayed a targeted uptake and higher inhibition of HepG2 cells. Additionally, PMSNs@DOX@FA had excellent ability to kill tumor cells under synergistic chemo-photothermal therapy. Moreover, this synthetic strategy is promising for the fabrication of unique nanocomposites with various functional cores with PMSNs shells for diverse applications." @default.
- W2899974179 created "2018-11-16" @default.
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- W2899974179 date "2018-01-01" @default.
- W2899974179 modified "2023-09-24" @default.
- W2899974179 title "One-pot synthesis of biodegradable polydopamine-doped mesoporous silica nanocomposites (PMSNs) as pH-sensitive targeting drug nanocarriers for synergistic chemo-photothermal therapy" @default.
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- W2899974179 doi "https://doi.org/10.1039/c8ra07467d" @default.
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