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- W2899983000 abstract "Antibiotic ResistanceAntibiotic resistance is an alarming and growing challenge. Bacteria show great heterogeneity in growth and mutation rates. Such variability allows some cells to persist during transient antibiotic exposure. During this persistent phase, mutations accumulate, which can result in selection for full-blown antibiotic resistance. El Meouche and Dunlop found that increased expression of efflux pumps on some cells affords them some relief from antibiotic toxicity. But up-regulating efflux pumps is costly for the bacteria, reducing growth rate and expression of MutS, a protein involved in DNA mismatch repair. These changes thus lift the lid on increased levels of bacterial mutation.Science , this issue p. [686][1] [1]: /lookup/doi/10.1126/science.aar7981" @default.
- W2899983000 created "2018-11-16" @default.
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- W2899983000 date "2018-11-08" @default.
- W2899983000 modified "2023-09-25" @default.
- W2899983000 title "Efflux pumps and mutation" @default.
- W2899983000 doi "https://doi.org/10.1126/science.362.6415.651-o" @default.
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