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• W2900043549 startingPage "475" @default.
• W2900043549 abstract "AS1411 is an antiproliferative DNA aptamer, which binds the ubiquitous protein, nucleolin. In this study, we show that constitutive overexpression of nucleolin confers increased sensitivity to the growth inhibitory effects of AS1411. HeLa cells overexpressing nucleolin have an increased growth rate and invasiveness relative to control cells. Nucleolin overexpressing cells demonstrate increased growth inhibition in response to the AS1411 treatment, which correlates with increased apoptosis and cell cycle arrest, when compared to non-transfected cells. AS1411 induces nucleolin expression at the RNA and protein level in HeLa cells, suggesting a feedback loop with important implications for the clinical use of AS1411." @default.
• W2900043549 created "2018-11-16" @default.
• W2900043549 creator A5035332660 @default.
• W2900043549 creator A5049995307 @default.
• W2900043549 creator A5061655023 @default.
• W2900043549 creator A5081648312 @default.
• W2900043549 date "2018-11-05" @default.
• W2900043549 modified "2023-09-25" @default.
• W2900043549 title "Nucleolin Overexpression Confers Increased Sensitivity to the Anti-Nucleolin Aptamer, AS1411" @default.
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• W2900043549 doi "https://doi.org/10.1080/07357907.2018.1527930" @default.
• W2900043549 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6396827" @default.
• W2900043549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30396283" @default.
• W2900043549 hasPublicationYear "2018" @default.
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