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- W2900102275 abstract "The staggered use of CT and near-infrared fluorescence imaging enables mapping of patient vasculature in surgeries involving free tissue transplantation. Visualization of tissue perfusion by CT determines surgical margins of donor site during pre-operative planning. Subsequent to this vascular mapping, fluorescence imaging with the dye indocyanine green (ICG) is used to intra-operatively assess blood flow during donor tissue implantation and later post-operatively evaluate the transplanted tissueâ s circulatory health in recipient sites. Considering the individual shortcomings of CT contrast media and ICG, the design of a CT, fluorescence a dual-modal agent would eliminate the need for separate contrast and imaging agent administration and combine pre-operative vascular architecture mapping by CT with the standard method of evaluating tissue circulatory health intra- and post-operatively by fluorescence. In this work, the fluorescent and X-ray attenuating properties of a CT, fluorescent active lipid nanoemulsion (LNE) formulation, have been characterized in vitro and in vivo.%%%%M.Sc.%%%%2018-11-06 00:00:00" @default.
- W2900102275 created "2018-11-16" @default.
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- W2900102275 date "2017-11-01" @default.
- W2900102275 modified "2023-09-23" @default.
- W2900102275 title "Fabrication of Lipid-Stabilized Oil-in-Water Nanoemulsions as Dual-Modal CT, Fluorescence Contrast Agents" @default.
- W2900102275 hasPublicationYear "2017" @default.
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