Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900108514> ?p ?o ?g. }
- W2900108514 abstract "The rhodopsin-VxPx-Arf4 complex initiates expansion of vertebrate rod photoreceptor cilia-derived light-sensing organelles through stepwise assembly of the conserved trafficking network. Here, we examine its role in the sorting of VAMP7/TI-VAMP—an R-SNARE possessing a regulatory longin domain (LD)—into rhodopsin transport carriers (RTCs). During RTC formation and trafficking, VAMP7 co-localizes with the ciliary cargo rhodopsin and interacts with the Rab11-Rabin8-Rab8 trafficking module. Rab11 and Rab8 bind VAMP7 LD, whereas Rabin8 interacts with the SNARE domain. The Arf/Rab11 effector FIP3 regulates VAMP7 access to Rab11. At the ciliary base, VAMP7 forms a complex with the cognate SNAREs syntaxin 3 and SNAP-25. When expressed in transgenic animals, GFP-VAMP7ΔLD fusion protein, and a Y45E phosphomimetic mutant, colocalize with endogenous VAMP7. GFP-VAMP7-R150E mutant displays considerable localization defects that imply an important role of the R-SNARE motif in intracellular trafficking, rather than cognate SNARE pairing. Our study defines the link between VAMP7 and the ciliary targeting nexus that is conserved across diverse cell types, and contributes to general understanding of how functional Arf and Rab networks assemble SNAREs in membrane trafficking." @default.
- W2900108514 created "2018-11-16" @default.
- W2900108514 creator A5017561547 @default.
- W2900108514 creator A5021532550 @default.
- W2900108514 creator A5039485380 @default.
- W2900108514 creator A5091797527 @default.
- W2900108514 date "2018-01-01" @default.
- W2900108514 modified "2023-09-27" @default.
- W2900108514 title "TI-VAMP/VAMP7-SNARE-Rab-GTPase interaction network within a ciliary membrane targeting complex" @default.
- W2900108514 cites W1577359987 @default.
- W2900108514 cites W1606949017 @default.
- W2900108514 cites W1822252127 @default.
- W2900108514 cites W1841184062 @default.
- W2900108514 cites W1950639483 @default.
- W2900108514 cites W1954666599 @default.
- W2900108514 cites W1964556094 @default.
- W2900108514 cites W1964573575 @default.
- W2900108514 cites W1965182896 @default.
- W2900108514 cites W1967368699 @default.
- W2900108514 cites W1973707501 @default.
- W2900108514 cites W1974781876 @default.
- W2900108514 cites W1976421227 @default.
- W2900108514 cites W1977767269 @default.
- W2900108514 cites W1978391620 @default.
- W2900108514 cites W1981403821 @default.
- W2900108514 cites W1981536301 @default.
- W2900108514 cites W1987644884 @default.
- W2900108514 cites W1987665348 @default.
- W2900108514 cites W1988488160 @default.
- W2900108514 cites W1992496728 @default.
- W2900108514 cites W1994668150 @default.
- W2900108514 cites W1996431885 @default.
- W2900108514 cites W2000302106 @default.
- W2900108514 cites W2002354443 @default.
- W2900108514 cites W2008321715 @default.
- W2900108514 cites W2009023199 @default.
- W2900108514 cites W2031062227 @default.
- W2900108514 cites W2031886668 @default.
- W2900108514 cites W2033371578 @default.
- W2900108514 cites W2039010865 @default.
- W2900108514 cites W2040707602 @default.
- W2900108514 cites W2046231980 @default.
- W2900108514 cites W2046743827 @default.
- W2900108514 cites W2047808133 @default.
- W2900108514 cites W2049413645 @default.
- W2900108514 cites W2053132003 @default.
- W2900108514 cites W2053451133 @default.
- W2900108514 cites W2056862039 @default.
- W2900108514 cites W2058810129 @default.
- W2900108514 cites W2064655401 @default.
- W2900108514 cites W2065810942 @default.
- W2900108514 cites W2066144077 @default.
- W2900108514 cites W2066780072 @default.
- W2900108514 cites W2077266233 @default.
- W2900108514 cites W2077451533 @default.
- W2900108514 cites W2077691322 @default.
- W2900108514 cites W2082252558 @default.
- W2900108514 cites W2083287420 @default.
- W2900108514 cites W208748842 @default.
- W2900108514 cites W2091521215 @default.
- W2900108514 cites W2092122970 @default.
- W2900108514 cites W2092636253 @default.
- W2900108514 cites W2097118390 @default.
- W2900108514 cites W2103478602 @default.
- W2900108514 cites W2104243614 @default.
- W2900108514 cites W2111256524 @default.
- W2900108514 cites W2111774440 @default.
- W2900108514 cites W2112488366 @default.
- W2900108514 cites W2114051740 @default.
- W2900108514 cites W2121634203 @default.
- W2900108514 cites W2124620233 @default.
- W2900108514 cites W2127440892 @default.
- W2900108514 cites W2127782546 @default.
- W2900108514 cites W2129409834 @default.
- W2900108514 cites W2131999768 @default.
- W2900108514 cites W2132328708 @default.
- W2900108514 cites W2134202521 @default.
- W2900108514 cites W2136002176 @default.
- W2900108514 cites W2138896791 @default.
- W2900108514 cites W2142523086 @default.
- W2900108514 cites W2143313571 @default.
- W2900108514 cites W2144944458 @default.
- W2900108514 cites W2145676689 @default.
- W2900108514 cites W2145677474 @default.
- W2900108514 cites W2147820111 @default.
- W2900108514 cites W2151819406 @default.
- W2900108514 cites W2155155386 @default.
- W2900108514 cites W2161464589 @default.
- W2900108514 cites W2161993137 @default.
- W2900108514 cites W2165412300 @default.
- W2900108514 cites W2167970399 @default.
- W2900108514 cites W2168923116 @default.
- W2900108514 cites W2170924711 @default.
- W2900108514 cites W2171152466 @default.
- W2900108514 cites W2179216232 @default.
- W2900108514 cites W2184527515 @default.
- W2900108514 cites W2218417668 @default.
- W2900108514 cites W2281917463 @default.
- W2900108514 cites W2287532417 @default.
- W2900108514 cites W2291971412 @default.