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- W2900144444 abstract "Summary Mammalian development requires effective mechanisms to repress genes whose expression would generate inappropriately specified cells. The Polycomb Repressive Complex 1 (PRC1) family complexes are central to maintaining this repression 1 . These include a set of canonical PRC1 complexes that each contain four core proteins, including one from the CBX family. These complexes have previously been shown to reside in membraneless organelles called Polycomb bodies, leading to speculation that canonical PRC1 might be found in a separate phase from the rest of the nucleus 2,3 . We show here that reconstituted PRC1 readily phase separates into droplets in vitro at low concentrations and physiological salt conditions. This behavior is driven by the CBX2 subunit. Point mutations in an internal domain of CBX2 eliminate phase separation. These same point mutations eliminate the formation of puncta in cells, and have previously been shown to eliminate nucleosome compaction in vitro 4 and to generate axial patterning defects in mice 5 . Thus, a single domain in CBX2 is required for phase separation and nucleosome compaction, a finding that relates these functions to each other and to proper development." @default.
- W2900144444 created "2018-11-16" @default.
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- W2900144444 date "2018-11-09" @default.
- W2900144444 modified "2023-09-29" @default.
- W2900144444 title "Phase separation and nucleosome compaction are governed by the same domain of Polycomb Repressive Complex 1" @default.
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- W2900144444 doi "https://doi.org/10.1101/467316" @default.
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