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- W2900153666 abstract "Abstract Acute disseminated encephalomyelitis (ADEM) is an immune-mediated, inflammatory demyelinating disease of the central nervous system that manifests with encephalopathy and polyfocal neurological signs and symptoms. Magnetic resonance imaging demonstrates large, ill-defined lesions predominantly affecting the white matter of the brain and spinal cord, though deep gray matter may be involved. A specific and sensitive biomarker for ADEM has yet to be discovered, though the utility of autoantibodies to myelin oligodendrocyte glycoprotein is currently under investigation. Diagnosis of ADEM is one of exclusion; however, consensus diagnostic definitions have facilitated a common terminology. ADEM is classically monophasic but rarely may exhibit a multiphasic course or may represent the first attack of a relapsing demyelinating disease, such as multiple sclerosis. Treatment consists of early immunotherapy and outcomes are mostly favorable. This chapter reviews the current knowledge of ADEM in a clinical context with specific focus on pathology, evaluation, diagnosis, treatment, and long-term outcomes." @default.
- W2900153666 created "2018-11-16" @default.
- W2900153666 creator A5078339501 @default.
- W2900153666 date "2018-01-01" @default.
- W2900153666 modified "2023-10-14" @default.
- W2900153666 title "Acute Disseminated Encephalomyelitis" @default.
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- W2900153666 doi "https://doi.org/10.1016/b978-0-12-811709-5.00017-x" @default.
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