FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900177789> ?p ?o ?g. }

• W2900177789 endingPage "1023" @default.
• W2900177789 startingPage "1016" @default.
• W2900177789 abstract "Cardiac hypertrophy are the major health challenges in the whole world. Ginsenoside Rd is an important component of cell growth and tumorigenesis, but the role and mechanism of ginsenoside Rd in pressure overload induced cardiac dysfunction and remodeling are still not fully illuminated. Here, cardiac hypertrophic remodeling and dysfunction were induced by pressure overload in mice. Myocardial histology was detected by Masson's trichrome staining and hematoxylin-eosin staining (H&E). Western blot was used to detect protein levels of signal mediators. Cardiac function was evaluated by echocardiography, and qPCR analysis was used to detect mRNA expression of hypertrophy and fibrosis markers. Cardiomyocyte size was detected by Wheat germ agglutinin (WGA) staining. Dihydroethidine (DHE) staining was used to detect oxidative stress. We also detected the influence of Ginsenoside Rd on rat neonatal cardiac myocytes (NRCMs) treated by Phenylephrine (PE). Our results showed that Ginsenoside Rd significantly improved pressure overload induced contractile dysfunction, fibrosis, cardiac hypertrophy, inflammation and oxidative stress in mice. Moreover, protein levels of AKT, calcineurin A, ERK1/2 and TGF-β1 were significantly decreased in the Ginsenoside Rd-treated hearts as compared to control. Ginsenoside Rd treated in cardiomyocytes inhibited PE-induced cardiomyocyte hypertrophy. These results revealed that ginsenoside Rd improved cardiac dysfunction and remodeling induced by pressure overload, which is related to the inhibition of a variety of signaling pathways." @default.
• W2900177789 created "2018-11-16" @default.
• W2900177789 creator A5017712497 @default.
• W2900177789 creator A5049160060 @default.
• W2900177789 creator A5053944900 @default.
• W2900177789 creator A5056595284 @default.
• W2900177789 creator A5057835954 @default.
• W2900177789 date "2019-01-01" @default.
• W2900177789 modified "2023-10-17" @default.
• W2900177789 title "Ginsenoside Rd contributes the attenuation of cardiac hypertrophy in vivo and in vitro" @default.
• W2900177789 cites W1566616288 @default.
• W2900177789 cites W1972012823 @default.
• W2900177789 cites W1978193310 @default.
• W2900177789 cites W1989194411 @default.
• W2900177789 cites W1989434611 @default.
• W2900177789 cites W1991748356 @default.
• W2900177789 cites W2005394580 @default.
• W2900177789 cites W2013608516 @default.
• W2900177789 cites W2014381522 @default.
• W2900177789 cites W2028091458 @default.
• W2900177789 cites W2040994228 @default.
• W2900177789 cites W2042264944 @default.
• W2900177789 cites W2046875912 @default.
• W2900177789 cites W2050774208 @default.
• W2900177789 cites W2054363389 @default.
• W2900177789 cites W2060714952 @default.
• W2900177789 cites W2069348282 @default.
• W2900177789 cites W2069982041 @default.
• W2900177789 cites W2088109209 @default.
• W2900177789 cites W2089547194 @default.
• W2900177789 cites W2103140414 @default.
• W2900177789 cites W2106908363 @default.
• W2900177789 cites W2109380338 @default.
• W2900177789 cites W2109608940 @default.
• W2900177789 cites W2118104419 @default.
• W2900177789 cites W2118559888 @default.
• W2900177789 cites W2129439677 @default.
• W2900177789 cites W2144989759 @default.
• W2900177789 cites W2147682535 @default.
• W2900177789 cites W2330218852 @default.
• W2900177789 cites W2334499091 @default.
• W2900177789 cites W2756376781 @default.
• W2900177789 cites W2765242947 @default.
• W2900177789 cites W2791325526 @default.
• W2900177789 cites W4232767515 @default.
• W2900177789 cites W4255009698 @default.
• W2900177789 doi "https://doi.org/10.1016/j.biopha.2018.10.081" @default.
• W2900177789 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30551351" @default.
• W2900177789 hasPublicationYear "2019" @default.
• W2900177789 type Work @default.
• W2900177789 sameAs 2900177789 @default.
• W2900177789 citedByCount "38" @default.
• W2900177789 countsByYear W29001777892019 @default.
• W2900177789 countsByYear W29001777892020 @default.
• W2900177789 countsByYear W29001777892021 @default.
• W2900177789 countsByYear W29001777892022 @default.
• W2900177789 countsByYear W29001777892023 @default.
• W2900177789 crossrefType "journal-article" @default.
• W2900177789 hasAuthorship W2900177789A5017712497 @default.
• W2900177789 hasAuthorship W2900177789A5049160060 @default.
• W2900177789 hasAuthorship W2900177789A5053944900 @default.
• W2900177789 hasAuthorship W2900177789A5056595284 @default.
• W2900177789 hasAuthorship W2900177789A5057835954 @default.
• W2900177789 hasBestOaLocation W29001777891 @default.
• W2900177789 hasConcept C126322002 @default.
• W2900177789 hasConcept C134018914 @default.
• W2900177789 hasConcept C163031210 @default.
• W2900177789 hasConcept C167414201 @default.
• W2900177789 hasConcept C2777420927 @default.
• W2900177789 hasConcept C2778271984 @default.
• W2900177789 hasConcept C2780559512 @default.
• W2900177789 hasConcept C3018763269 @default.
• W2900177789 hasConcept C3018791406 @default.
• W2900177789 hasConcept C71924100 @default.
• W2900177789 hasConceptScore W2900177789C126322002 @default.
• W2900177789 hasConceptScore W2900177789C134018914 @default.
• W2900177789 hasConceptScore W2900177789C163031210 @default.
• W2900177789 hasConceptScore W2900177789C167414201 @default.
• W2900177789 hasConceptScore W2900177789C2777420927 @default.
• W2900177789 hasConceptScore W2900177789C2778271984 @default.
• W2900177789 hasConceptScore W2900177789C2780559512 @default.
• W2900177789 hasConceptScore W2900177789C3018763269 @default.
• W2900177789 hasConceptScore W2900177789C3018791406 @default.
• W2900177789 hasConceptScore W2900177789C71924100 @default.
• W2900177789 hasFunder F4320321001 @default.
• W2900177789 hasLocation W29001777891 @default.
• W2900177789 hasOpenAccess W2900177789 @default.
• W2900177789 hasPrimaryLocation W29001777891 @default.
• W2900177789 hasRelatedWork W196060227 @default.
• W2900177789 hasRelatedWork W2033771516 @default.
• W2900177789 hasRelatedWork W2054165882 @default.
• W2900177789 hasRelatedWork W2081680973 @default.
• W2900177789 hasRelatedWork W2418548996 @default.
• W2900177789 hasRelatedWork W2779089668 @default.
• W2900177789 hasRelatedWork W2783430812 @default.
• W2900177789 hasRelatedWork W2804917360 @default.
• W2900177789 hasRelatedWork W3121430770 @default.
• W2900177789 hasRelatedWork W3188474217 @default.

• next