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• W2900183821 abstract "Oxylipins, a subclass of lipid mediators, are metabolites of various polyunsaturated fatty acids with crucial functions in regulation of systemic inflammation. Elucidation of their roles in pathological conditions requires accurate quantification of their levels in biological samples. We refined an ultra-performance liquid chromatography-multiple reaction monitoring-mass spectrometry (UPLC-MRM-MS)-based workflow for comprehensive and specific quantification of 131 endogenous oxylipins in human plasma, in which we optimized LC mobile phase additives, column, and gradient conditions. We employed heatmap-assisted strategy to identify unique transitions to improve the assay selectivity and optimized solid phase extraction procedures to achieve better analyte recovery. The method was validated according to FDA guidelines. Overall, 94.4% and 95.7% of analytes at tested concentrations were within acceptable accuracy (80–120%) and precision (CV < 15%), respectively. Good linearity for most analytes was obtained with R2 > 0.99. The method was also validated using a standard reference material—SRM 1950 frozen human plasma to demonstrate inter-lab compatibility." @default.
• W2900183821 created "2018-11-16" @default.
• W2900183821 creator A5039723064 @default.
• W2900183821 creator A5076614493 @default.
• W2900183821 date "2018-11-08" @default.
• W2900183821 modified "2023-10-18" @default.
• W2900183821 title "Comprehensive analysis of oxylipins in human plasma using reversed-phase liquid chromatography-triple quadrupole mass spectrometry with heatmap-assisted selection of transitions" @default.
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• W2900183821 doi "https://doi.org/10.1007/s00216-018-1446-3" @default.
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