Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900184594> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2900184594 endingPage "152.21" @default.
- W2900184594 startingPage "152.21" @default.
- W2900184594 abstract "Abstract Maturation of the antibody response entails Ig class switch DNA recombination (CSR) and somatic hypermutation (SHM), which perfect the antigen-binding activity and diversify the effector functions of antibodies. By showing that HDAC inhibitors selective for class I/II HDACs dampened CSR and SHM by downregulating AID through upregulation of selected microRNAs that target Aicda, we have outlined an important role of these Zn-dependent HADCs in the modulation of the antibody response. Here we showed that Sirt1, one of the NAD+-dependent Class III HDACs or Sirtuins, also plays an important role in the regulation of B cell CSR and SHM. Sirt1 deletion in AID-expressing B cells of AicdacreSirt1fl/fl mice, whose B cells contain the normal complement of Aicda genes together with a Cre gene under control of an extra Aicda promoter, led to increased class-switched and somatically mutated antibodies in response to NP-CGG, as a result of upregulated AID expression, without alteration of Prdm1 expression or plasma cell differentiation. Sirt1-deficient B cells hyperacetylated p65, thereby activating the canonical NF-kB pathway, which mediates Aicda activation, without changes in DNA methylation or histone acetylation of the Aicda promoter. This was mimicked by increased concentrations of glucose, which reduced the NAD+ Sirt1 co-factor, leading to p65 hyperacetylation and Aicda upregulation in B cells. Conversely, treatment of B cells with NAD+ or SRT1720, a potent Sirt1 activator, dampened Aicda expression. Thus, our findings outline an important B cell-intrinsic role of Sirt1 in the modulation of the antibody response." @default.
- W2900184594 created "2018-11-16" @default.
- W2900184594 creator A5046138175 @default.
- W2900184594 creator A5046159238 @default.
- W2900184594 creator A5047842458 @default.
- W2900184594 creator A5050558897 @default.
- W2900184594 creator A5057099506 @default.
- W2900184594 creator A5064197525 @default.
- W2900184594 creator A5084518142 @default.
- W2900184594 date "2017-05-01" @default.
- W2900184594 modified "2023-10-16" @default.
- W2900184594 title "Sirt1 modulates immunoglobulin class switch DNA recombination and somatic hypermutation by regulating B lymphocyte <i>Aicda</i> expression through NF-kB deacetylation" @default.
- W2900184594 doi "https://doi.org/10.4049/jimmunol.198.supp.152.21" @default.
- W2900184594 hasPublicationYear "2017" @default.
- W2900184594 type Work @default.
- W2900184594 sameAs 2900184594 @default.
- W2900184594 citedByCount "0" @default.
- W2900184594 crossrefType "journal-article" @default.
- W2900184594 hasAuthorship W2900184594A5046138175 @default.
- W2900184594 hasAuthorship W2900184594A5046159238 @default.
- W2900184594 hasAuthorship W2900184594A5047842458 @default.
- W2900184594 hasAuthorship W2900184594A5050558897 @default.
- W2900184594 hasAuthorship W2900184594A5057099506 @default.
- W2900184594 hasAuthorship W2900184594A5064197525 @default.
- W2900184594 hasAuthorship W2900184594A5084518142 @default.
- W2900184594 hasConcept C104317684 @default.
- W2900184594 hasConcept C127561419 @default.
- W2900184594 hasConcept C128526571 @default.
- W2900184594 hasConcept C137756551 @default.
- W2900184594 hasConcept C153911025 @default.
- W2900184594 hasConcept C159654299 @default.
- W2900184594 hasConcept C27082348 @default.
- W2900184594 hasConcept C2776985229 @default.
- W2900184594 hasConcept C2778453870 @default.
- W2900184594 hasConcept C54355233 @default.
- W2900184594 hasConcept C86803240 @default.
- W2900184594 hasConceptScore W2900184594C104317684 @default.
- W2900184594 hasConceptScore W2900184594C127561419 @default.
- W2900184594 hasConceptScore W2900184594C128526571 @default.
- W2900184594 hasConceptScore W2900184594C137756551 @default.
- W2900184594 hasConceptScore W2900184594C153911025 @default.
- W2900184594 hasConceptScore W2900184594C159654299 @default.
- W2900184594 hasConceptScore W2900184594C27082348 @default.
- W2900184594 hasConceptScore W2900184594C2776985229 @default.
- W2900184594 hasConceptScore W2900184594C2778453870 @default.
- W2900184594 hasConceptScore W2900184594C54355233 @default.
- W2900184594 hasConceptScore W2900184594C86803240 @default.
- W2900184594 hasIssue "1_Supplement" @default.
- W2900184594 hasLocation W29001845941 @default.
- W2900184594 hasOpenAccess W2900184594 @default.
- W2900184594 hasPrimaryLocation W29001845941 @default.
- W2900184594 hasRelatedWork W1973389611 @default.
- W2900184594 hasRelatedWork W1976289621 @default.
- W2900184594 hasRelatedWork W1985389664 @default.
- W2900184594 hasRelatedWork W2048365604 @default.
- W2900184594 hasRelatedWork W2067608841 @default.
- W2900184594 hasRelatedWork W2070077942 @default.
- W2900184594 hasRelatedWork W2075634030 @default.
- W2900184594 hasRelatedWork W2081545687 @default.
- W2900184594 hasRelatedWork W2349842709 @default.
- W2900184594 hasRelatedWork W2597278165 @default.
- W2900184594 hasVolume "198" @default.
- W2900184594 isParatext "false" @default.
- W2900184594 isRetracted "false" @default.
- W2900184594 magId "2900184594" @default.
- W2900184594 workType "article" @default.