FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900188889> ?p ?o ?g. }

• W2900188889 endingPage "427" @default.
• W2900188889 startingPage "421" @default.
• W2900188889 abstract "Abstract Background Infection with the gram-negative bacterium Burkholderia pseudomallei can result in melioidosis, a life-threatening disease that can be difficult to diagnose. Culture remains the gold standard for diagnosis but requires laboratory resources not available in many endemic regions. A lateral flow immunoassay has shown promise for POC diagnostics but suffers from low sensitivity when used on blood samples. PCR also has low sensitivity on blood, attributed to the low bacterial numbers in blood observed in melioidosis patients, even when bacteraemic. Methods A prototype i-STAT cartridge was developed to utilize the monoclonal antibody specific for the capsule of pathogenic Burkholderia species employed on the LFI. The resulting POC assay was evaluated on 414 clinical specimens from Darwin, Australia and Cambodia. Results The i-STAT assay accurately distinguished Australian blood culture positive melioidosis patients from Australian patients hospitalized with other infections (AUC = 0.91, 95% CI 0.817 - 1.0). We derived an assay cutoff with 76% sensitivity and 94% specificity that correctly classified 88% (n = 74) of the Australian patients. Interestingly, only 46% (6/13) of the culture-positive melioidosis patients in Cambodia were classified correctly. Of great importance however, the assay detected capsule from blood samples for 32% of blood culture negative melioidosis patients in both cohorts and previously undiagnosed melioidosis patients in Cambodia. In addition the assay showed high sensitivity and specificity for urine, pus and sputum. Conclusions Diagnostic tools that are not dependent upon the growth kinetics or the levels of bacteremia of B. pseudomallei represent the next-generation of diagnostics and must be pursued further." @default.
• W2900188889 created "2018-11-16" @default.
• W2900188889 creator A5013337417 @default.
• W2900188889 creator A5018674620 @default.
• W2900188889 creator A5022996096 @default.
• W2900188889 creator A5027313644 @default.
• W2900188889 creator A5028445176 @default.
• W2900188889 creator A5035207865 @default.
• W2900188889 creator A5035952225 @default.
• W2900188889 creator A5050904562 @default.
• W2900188889 creator A5052456396 @default.
• W2900188889 creator A5069401929 @default.
• W2900188889 creator A5069593392 @default.
• W2900188889 creator A5091067654 @default.
• W2900188889 date "2018-10-31" @default.
• W2900188889 modified "2023-09-26" @default.
• W2900188889 title "Next-generation Diagnostics for Melioidosis: Evaluation of a Prototype i-STAT Cartridge to Detect Burkholderia pseudomallei Biomarkers" @default.
• W2900188889 cites W1930468266 @default.
• W2900188889 cites W1972058172 @default.
• W2900188889 cites W2029921002 @default.
• W2900188889 cites W2035788663 @default.
• W2900188889 cites W2038576217 @default.
• W2900188889 cites W2076553156 @default.
• W2900188889 cites W2076635087 @default.
• W2900188889 cites W2107966948 @default.
• W2900188889 cites W2112760723 @default.
• W2900188889 cites W2113384992 @default.
• W2900188889 cites W2127510572 @default.
• W2900188889 cites W2135485869 @default.
• W2900188889 cites W2142516915 @default.
• W2900188889 cites W2171206637 @default.
• W2900188889 cites W2407415576 @default.
• W2900188889 cites W2755364332 @default.
• W2900188889 cites W2789795758 @default.
• W2900188889 cites W2795063120 @default.
• W2900188889 cites W2801821172 @default.
• W2900188889 cites W4232360806 @default.
• W2900188889 cites W975862196 @default.
• W2900188889 doi "https://doi.org/10.1093/cid/ciy929" @default.
• W2900188889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30403768" @default.
• W2900188889 hasPublicationYear "2018" @default.
• W2900188889 type Work @default.
• W2900188889 sameAs 2900188889 @default.
• W2900188889 citedByCount "7" @default.
• W2900188889 countsByYear W29001888892020 @default.
• W2900188889 countsByYear W29001888892021 @default.
• W2900188889 countsByYear W29001888892022 @default.
• W2900188889 countsByYear W29001888892023 @default.
• W2900188889 crossrefType "journal-article" @default.
• W2900188889 hasAuthorship W2900188889A5013337417 @default.
• W2900188889 hasAuthorship W2900188889A5018674620 @default.
• W2900188889 hasAuthorship W2900188889A5022996096 @default.
• W2900188889 hasAuthorship W2900188889A5027313644 @default.
• W2900188889 hasAuthorship W2900188889A5028445176 @default.
• W2900188889 hasAuthorship W2900188889A5035207865 @default.
• W2900188889 hasAuthorship W2900188889A5035952225 @default.
• W2900188889 hasAuthorship W2900188889A5050904562 @default.
• W2900188889 hasAuthorship W2900188889A5052456396 @default.
• W2900188889 hasAuthorship W2900188889A5069401929 @default.
• W2900188889 hasAuthorship W2900188889A5069593392 @default.
• W2900188889 hasAuthorship W2900188889A5091067654 @default.
• W2900188889 hasConcept C126322002 @default.
• W2900188889 hasConcept C142724271 @default.
• W2900188889 hasConcept C203014093 @default.
• W2900188889 hasConcept C2776301714 @default.
• W2900188889 hasConcept C2779110727 @default.
• W2900188889 hasConcept C2779443120 @default.
• W2900188889 hasConcept C2779473907 @default.
• W2900188889 hasConcept C2779775996 @default.
• W2900188889 hasConcept C2781069245 @default.
• W2900188889 hasConcept C40993552 @default.
• W2900188889 hasConcept C501593827 @default.
• W2900188889 hasConcept C523546767 @default.
• W2900188889 hasConcept C54355233 @default.
• W2900188889 hasConcept C71924100 @default.
• W2900188889 hasConcept C86803240 @default.
• W2900188889 hasConcept C89423630 @default.
• W2900188889 hasConceptScore W2900188889C126322002 @default.
• W2900188889 hasConceptScore W2900188889C142724271 @default.
• W2900188889 hasConceptScore W2900188889C203014093 @default.
• W2900188889 hasConceptScore W2900188889C2776301714 @default.
• W2900188889 hasConceptScore W2900188889C2779110727 @default.
• W2900188889 hasConceptScore W2900188889C2779443120 @default.
• W2900188889 hasConceptScore W2900188889C2779473907 @default.
• W2900188889 hasConceptScore W2900188889C2779775996 @default.
• W2900188889 hasConceptScore W2900188889C2781069245 @default.
• W2900188889 hasConceptScore W2900188889C40993552 @default.
• W2900188889 hasConceptScore W2900188889C501593827 @default.
• W2900188889 hasConceptScore W2900188889C523546767 @default.
• W2900188889 hasConceptScore W2900188889C54355233 @default.
• W2900188889 hasConceptScore W2900188889C71924100 @default.
• W2900188889 hasConceptScore W2900188889C86803240 @default.
• W2900188889 hasConceptScore W2900188889C89423630 @default.
• W2900188889 hasIssue "3" @default.
• W2900188889 hasLocation W29001888891 @default.
• W2900188889 hasOpenAccess W2900188889 @default.
• W2900188889 hasPrimaryLocation W29001888891 @default.
• W2900188889 hasRelatedWork W2101960377 @default.

• next