FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900199744> ?p ?o ?g. }

• W2900199744 endingPage "3190" @default.
• W2900199744 startingPage "3183" @default.
• W2900199744 abstract "Since Alan Turing's 1952 pioneering work, reaction-diffusion (RD) processes are regarded as prototype mechanisms for pattern formation in living systems. Though suspected in many aspects of morphogenetic development, pure RD patterns have not yet been demonstrated in living organisms. The first observations of an autonomous development of stationary chemical patterns were made in the early 1990s. In this Account, we discuss the recent developments for producing stationary pH RD patterns in open spatial reactors. The theoretical analysis of the early experiments anticipated the possibility of finding Turing patterns in a wide range of oscillatory reactions if one could control the kinetic and diffusional rate of some key species. However, no experimentally effective method to produce stationary Turing patterns was attained before 2009, and the number of systems stagnated at two until then. The two precursor reaction systems benefited from unplanned favorable chemical properties of the RD media. Theoretical studies point out that appropriate diffusion rate differences are necessary to produce stationary patterns since a competition between an effective short distance self-activation and a long distance inhibitory process is required. This differential diffusion would naturally lead to differential exchange rates between the RD system and its feed environment, an aspect somewhat overlooked in theoretical and in primal experimental approaches. Our pattern design method takes this aspect into account. A slower diffusion of a self-activated species (here, protons), produced in the RD part of the spatial reactor, generates the accumulation of this species compared to the other species. This accumulation has to be at least partly compensated by an independent scavenging reaction. The above requirement naturally brought us to focus on two-substrate pH oscillatory reactions. Stationary RD patterns are now well documented in six pH driven reaction systems. Furthermore, the coupling with a pH dependent metal ion complexing agent led to stationary patterns in calcium ion concentration. Our effective semiempirical design method does not require a detailed knowledge of the reaction kinetics; thus it is applicable to a broad spectrum of reactions and even to synthetic biological systems. It is based on simple dynamic arguments and on general topological characteristics of a nonequilibrium phase diagram. We first illustrate our method with numerical simulations, based on a realistic but idealized general model of the two-substrate pH-oscillator reaction family, and provide a refined view of the topology of the resulting phase diagrams. Then, we exemplify its effectiveness by observations made in distinct pH self-activated systems. Analogies and differences between experiments and the model calculations are pointed out. Besides standard hexagonal arrays of spots and parallel stripes, hitherto undocumented dynamic phenomena, such as randomly blinking areas and complex dynamic and stationary filamentous structures, were observed. The main challenge, to find low-mobility complexing agents that would selectively and reversibly bind a species controlling the self-activatory kinetic path of the reaction, was readily overcome in multiple ways by anions of weak acids: not only by polymeric substances but in some cases by a pH color indicator or even smaller molecules, depending on their proton binding affinity." @default.
• W2900199744 created "2018-11-16" @default.
• W2900199744 creator A5008961066 @default.
• W2900199744 creator A5017412943 @default.
• W2900199744 creator A5026908556 @default.
• W2900199744 date "2018-11-09" @default.
• W2900199744 modified "2023-10-17" @default.
• W2900199744 title "Designing Stationary Reaction–Diffusion Patterns in pH Self-Activated Systems" @default.
• W2900199744 cites W1978491683 @default.
• W2900199744 cites W1980661496 @default.
• W2900199744 cites W1986104761 @default.
• W2900199744 cites W1991934068 @default.
• W2900199744 cites W1998538028 @default.
• W2900199744 cites W2024748736 @default.
• W2900199744 cites W2028323972 @default.
• W2900199744 cites W2029649578 @default.
• W2900199744 cites W2033571080 @default.
• W2900199744 cites W2036754112 @default.
• W2900199744 cites W2037486322 @default.
• W2900199744 cites W2042433747 @default.
• W2900199744 cites W2047506587 @default.
• W2900199744 cites W2050673676 @default.
• W2900199744 cites W2052448416 @default.
• W2900199744 cites W2057669106 @default.
• W2900199744 cites W2059160074 @default.
• W2900199744 cites W2065529729 @default.
• W2900199744 cites W2067172337 @default.
• W2900199744 cites W2092424552 @default.
• W2900199744 cites W2093708215 @default.
• W2900199744 cites W2133137844 @default.
• W2900199744 cites W2143489502 @default.
• W2900199744 cites W2170830970 @default.
• W2900199744 cites W2314095208 @default.
• W2900199744 cites W2342266478 @default.
• W2900199744 cites W601827430 @default.
• W2900199744 doi "https://doi.org/10.1021/acs.accounts.8b00441" @default.
• W2900199744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30412377" @default.
• W2900199744 hasPublicationYear "2018" @default.
• W2900199744 type Work @default.
• W2900199744 sameAs 2900199744 @default.
• W2900199744 citedByCount "14" @default.
• W2900199744 countsByYear W29001997442020 @default.
• W2900199744 countsByYear W29001997442021 @default.
• W2900199744 countsByYear W29001997442022 @default.
• W2900199744 countsByYear W29001997442023 @default.
• W2900199744 crossrefType "journal-article" @default.
• W2900199744 hasAuthorship W2900199744A5008961066 @default.
• W2900199744 hasAuthorship W2900199744A5017412943 @default.
• W2900199744 hasAuthorship W2900199744A5026908556 @default.
• W2900199744 hasConcept C121231716 @default.
• W2900199744 hasConcept C121332964 @default.
• W2900199744 hasConcept C121864883 @default.
• W2900199744 hasConcept C159467904 @default.
• W2900199744 hasConcept C159985019 @default.
• W2900199744 hasConcept C185592680 @default.
• W2900199744 hasConcept C186060115 @default.
• W2900199744 hasConcept C18762648 @default.
• W2900199744 hasConcept C18903297 @default.
• W2900199744 hasConcept C192562407 @default.
• W2900199744 hasConcept C199360897 @default.
• W2900199744 hasConcept C204323151 @default.
• W2900199744 hasConcept C207016750 @default.
• W2900199744 hasConcept C41008148 @default.
• W2900199744 hasConcept C54355233 @default.
• W2900199744 hasConcept C69357855 @default.
• W2900199744 hasConcept C86803240 @default.
• W2900199744 hasConcept C91306197 @default.
• W2900199744 hasConcept C97355855 @default.
• W2900199744 hasConcept C9870796 @default.
• W2900199744 hasConceptScore W2900199744C121231716 @default.
• W2900199744 hasConceptScore W2900199744C121332964 @default.
• W2900199744 hasConceptScore W2900199744C121864883 @default.
• W2900199744 hasConceptScore W2900199744C159467904 @default.
• W2900199744 hasConceptScore W2900199744C159985019 @default.
• W2900199744 hasConceptScore W2900199744C185592680 @default.
• W2900199744 hasConceptScore W2900199744C186060115 @default.
• W2900199744 hasConceptScore W2900199744C18762648 @default.
• W2900199744 hasConceptScore W2900199744C18903297 @default.
• W2900199744 hasConceptScore W2900199744C192562407 @default.
• W2900199744 hasConceptScore W2900199744C199360897 @default.
• W2900199744 hasConceptScore W2900199744C204323151 @default.
• W2900199744 hasConceptScore W2900199744C207016750 @default.
• W2900199744 hasConceptScore W2900199744C41008148 @default.
• W2900199744 hasConceptScore W2900199744C54355233 @default.
• W2900199744 hasConceptScore W2900199744C69357855 @default.
• W2900199744 hasConceptScore W2900199744C86803240 @default.
• W2900199744 hasConceptScore W2900199744C91306197 @default.
• W2900199744 hasConceptScore W2900199744C97355855 @default.
• W2900199744 hasConceptScore W2900199744C9870796 @default.
• W2900199744 hasFunder F4320321994 @default.
• W2900199744 hasIssue "12" @default.
• W2900199744 hasLocation W29001997441 @default.
• W2900199744 hasLocation W29001997442 @default.
• W2900199744 hasLocation W29001997443 @default.
• W2900199744 hasLocation W29001997444 @default.
• W2900199744 hasOpenAccess W2900199744 @default.
• W2900199744 hasPrimaryLocation W29001997441 @default.
• W2900199744 hasRelatedWork W1991947259 @default.

• next