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- W2900205575 abstract "WSSV is the deadliest viral pathogen threatening global shrimp aquaculture. The evolutionary history of WSSV has remained a mystery, because few WSSV relatives, or nimaviruses, had been reported. Our aim was to trace the history of WSSV using the genomes of novel nimaviruses hidden in host genome data. We demonstrate that WSSV emerged from a diverse family of crustacean-infecting large DNA viruses. By comparing the genomes of WSSV and its relatives, we show that WSSV possesses an expanded set of unique host-virus interaction-related genes. This extensive gene gain may have been the key genomic event that made WSSV such a deadly pathogen. Moreover, conservation of insect-infecting virus protein homologs suggests a common phylogenetic origin of crustacean-infecting Nimaviridae and other insect-infecting DNA viruses. Our work redefines the previously poorly characterized crustacean virus family and reveals the ancient genomic events that preordained the emergence of a devastating shrimp pathogen." @default.
- W2900205575 created "2018-11-16" @default.
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- W2900205575 date "2019-02-01" @default.
- W2900205575 modified "2023-10-10" @default.
- W2900205575 title "Crustacean Genome Exploration Reveals the Evolutionary Origin of White Spot Syndrome Virus" @default.
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- W2900205575 doi "https://doi.org/10.1128/jvi.01144-18" @default.
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