Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900237557> ?p ?o ?g. }
- W2900237557 endingPage "15" @default.
- W2900237557 startingPage "7" @default.
- W2900237557 abstract "Suicidal behavior is a complex human behavior and current data suggests that suicide is an increasing cause of death among young people. The neurobiology of suicide is unknown and data investigating the role of the pituitary in suicidal behavior is scarce. Imaging data suggests that this gland increases in size in patients with major depression and recent data implicates hyperactivity of the hypothalamus-pituitary-adrenal axis in suicidal behavior. In this study, we evaluate the size and number of cells as well as markers related to oxidative stress and lipid peroxidation of the anterior and posterior sections of the pituitary gland of male suicide completers. Stereological analysis is used to quantify the total cell number in anterior- and posterior-pituitary regions. We examined nitric oxide (NO) levels, Zinc (Zn) levels, superoxide dismutase (SOD) activity, 4-hydroxy-alkenals (4-HDA), malondialdehyde (MDA) and metallothioneins (MTs). Our results indicate that the anterior-pituitary region of suicide completers exhibits increased weight, likely due to an enhanced number of cells compared to the control group. In addition, we found a reduction of NO levels with higher SOD activity in the anterior-pituitary region of suicide victims. No changes in Zn, MDA, MTs, 4-HDA or MDA were observed in tissue of suicide completers compared to the control group. This study demonstrates that there is an increased number of cells, with an imbalance in oxidative stress without a process of lipid peroxidation in the anterior-pituitary region of young male suicide completers." @default.
- W2900237557 created "2018-11-16" @default.
- W2900237557 creator A5003257738 @default.
- W2900237557 creator A5006522972 @default.
- W2900237557 creator A5012752153 @default.
- W2900237557 creator A5013687245 @default.
- W2900237557 creator A5027226585 @default.
- W2900237557 creator A5028685500 @default.
- W2900237557 creator A5029656168 @default.
- W2900237557 creator A5031348642 @default.
- W2900237557 creator A5044385079 @default.
- W2900237557 creator A5046280357 @default.
- W2900237557 creator A5052980208 @default.
- W2900237557 creator A5074115323 @default.
- W2900237557 creator A5080833451 @default.
- W2900237557 date "2019-03-01" @default.
- W2900237557 modified "2023-10-06" @default.
- W2900237557 title "Increased cell number with reduced nitric oxide level and augmented superoxide dismutase activity in the anterior-pituitary region of young suicide completers" @default.
- W2900237557 cites W1702526289 @default.
- W2900237557 cites W1938721358 @default.
- W2900237557 cites W1941758145 @default.
- W2900237557 cites W1968876090 @default.
- W2900237557 cites W1969001174 @default.
- W2900237557 cites W1972606804 @default.
- W2900237557 cites W1979738397 @default.
- W2900237557 cites W1982232439 @default.
- W2900237557 cites W1986761481 @default.
- W2900237557 cites W1986875797 @default.
- W2900237557 cites W1988666067 @default.
- W2900237557 cites W2007549067 @default.
- W2900237557 cites W2012097016 @default.
- W2900237557 cites W2012989541 @default.
- W2900237557 cites W2014087704 @default.
- W2900237557 cites W2015205503 @default.
- W2900237557 cites W2016313015 @default.
- W2900237557 cites W2022510326 @default.
- W2900237557 cites W2024862570 @default.
- W2900237557 cites W2025951092 @default.
- W2900237557 cites W2028072333 @default.
- W2900237557 cites W2028274535 @default.
- W2900237557 cites W2038083677 @default.
- W2900237557 cites W2040208650 @default.
- W2900237557 cites W2043840611 @default.
- W2900237557 cites W2044906091 @default.
- W2900237557 cites W2045470216 @default.
- W2900237557 cites W2045982598 @default.
- W2900237557 cites W2049480277 @default.
- W2900237557 cites W2051764711 @default.
- W2900237557 cites W2052459220 @default.
- W2900237557 cites W2056204707 @default.
- W2900237557 cites W2056825582 @default.
- W2900237557 cites W2058077554 @default.
- W2900237557 cites W2058440461 @default.
- W2900237557 cites W2059858969 @default.
- W2900237557 cites W2060468971 @default.
- W2900237557 cites W2062170689 @default.
- W2900237557 cites W2062384458 @default.
- W2900237557 cites W2064473116 @default.
- W2900237557 cites W2064666556 @default.
- W2900237557 cites W2067471020 @default.
- W2900237557 cites W2073117140 @default.
- W2900237557 cites W2075962869 @default.
- W2900237557 cites W2077831878 @default.
- W2900237557 cites W2080683009 @default.
- W2900237557 cites W2081072005 @default.
- W2900237557 cites W2082221119 @default.
- W2900237557 cites W2083875917 @default.
- W2900237557 cites W2084086773 @default.
- W2900237557 cites W2088866343 @default.
- W2900237557 cites W2096047662 @default.
- W2900237557 cites W2098093726 @default.
- W2900237557 cites W2105719215 @default.
- W2900237557 cites W2119045564 @default.
- W2900237557 cites W2123208217 @default.
- W2900237557 cites W2128249118 @default.
- W2900237557 cites W2148337554 @default.
- W2900237557 cites W2149033779 @default.
- W2900237557 cites W2157219711 @default.
- W2900237557 cites W2247931251 @default.
- W2900237557 cites W2248268075 @default.
- W2900237557 cites W2256679287 @default.
- W2900237557 cites W2337478268 @default.
- W2900237557 cites W2570996757 @default.
- W2900237557 cites W2604383672 @default.
- W2900237557 cites W2611406986 @default.
- W2900237557 cites W2734892204 @default.
- W2900237557 cites W2744004885 @default.
- W2900237557 cites W2762170115 @default.
- W2900237557 cites W2768053761 @default.
- W2900237557 cites W2778724589 @default.
- W2900237557 cites W2791642915 @default.
- W2900237557 cites W2793397878 @default.
- W2900237557 cites W2794229663 @default.
- W2900237557 cites W2802266639 @default.
- W2900237557 cites W4211097259 @default.
- W2900237557 doi "https://doi.org/10.1016/j.jchemneu.2018.11.002" @default.
- W2900237557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30423351" @default.
- W2900237557 hasPublicationYear "2019" @default.