Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900280130> ?p ?o ?g. }
- W2900280130 endingPage "3472" @default.
- W2900280130 startingPage "3472" @default.
- W2900280130 abstract "The high interest in N-Heterocyclic platinum carbene complexes in cancer research stems from their high cytotoxicity to human cancer cells, their stability, as well as their ease of functionalization. However, the development of these new molecules as anticancer agents still faces multiple challenges, in particular solubility in aqueous media. Here, we synthesized platinum-NHC bioconjugates that combine water-solubility and cytotoxicity by using polyethyleneimine as polymer carrier. We showed on 8 different types of cells that the activity of these conjugates is modulated by the size of the polymer and the overall density of metal ions onto polymer chains. Using HCT116 cells, the conjugates displayed an effective activity after only 45 min of exposure in vitro correlated with a quick uptake by the cells as shown by the use of various fluorescent-tagged derivatives." @default.
- W2900280130 created "2018-11-16" @default.
- W2900280130 creator A5001030779 @default.
- W2900280130 creator A5001159176 @default.
- W2900280130 creator A5022701026 @default.
- W2900280130 creator A5028182248 @default.
- W2900280130 creator A5030004931 @default.
- W2900280130 creator A5077682751 @default.
- W2900280130 date "2018-11-05" @default.
- W2900280130 modified "2023-09-25" @default.
- W2900280130 title "N-Heterocyclic Carbene-Polyethyleneimine (PEI) Platinum Complexes Inducing Human Cancer Cell Death: Polymer Carrier Impact" @default.
- W2900280130 cites W1491683183 @default.
- W2900280130 cites W1640703157 @default.
- W2900280130 cites W1963719070 @default.
- W2900280130 cites W1980411311 @default.
- W2900280130 cites W1994354502 @default.
- W2900280130 cites W2010655741 @default.
- W2900280130 cites W2013168545 @default.
- W2900280130 cites W2017356685 @default.
- W2900280130 cites W2022751983 @default.
- W2900280130 cites W2029434164 @default.
- W2900280130 cites W2034023714 @default.
- W2900280130 cites W2042457090 @default.
- W2900280130 cites W2048458014 @default.
- W2900280130 cites W2051415805 @default.
- W2900280130 cites W2087414776 @default.
- W2900280130 cites W2333005525 @default.
- W2900280130 cites W2474601761 @default.
- W2900280130 cites W2496353017 @default.
- W2900280130 cites W2952165521 @default.
- W2900280130 doi "https://doi.org/10.3390/ijms19113472" @default.
- W2900280130 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6274957" @default.
- W2900280130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30400637" @default.
- W2900280130 hasPublicationYear "2018" @default.
- W2900280130 type Work @default.
- W2900280130 sameAs 2900280130 @default.
- W2900280130 citedByCount "11" @default.
- W2900280130 countsByYear W29002801302019 @default.
- W2900280130 countsByYear W29002801302020 @default.
- W2900280130 countsByYear W29002801302021 @default.
- W2900280130 countsByYear W29002801302022 @default.
- W2900280130 crossrefType "journal-article" @default.
- W2900280130 hasAuthorship W2900280130A5001030779 @default.
- W2900280130 hasAuthorship W2900280130A5001159176 @default.
- W2900280130 hasAuthorship W2900280130A5022701026 @default.
- W2900280130 hasAuthorship W2900280130A5028182248 @default.
- W2900280130 hasAuthorship W2900280130A5030004931 @default.
- W2900280130 hasAuthorship W2900280130A5077682751 @default.
- W2900280130 hasBestOaLocation W29002801301 @default.
- W2900280130 hasConcept C109316439 @default.
- W2900280130 hasConcept C115537861 @default.
- W2900280130 hasConcept C121332964 @default.
- W2900280130 hasConcept C121608353 @default.
- W2900280130 hasConcept C12554922 @default.
- W2900280130 hasConcept C134306372 @default.
- W2900280130 hasConcept C147789679 @default.
- W2900280130 hasConcept C155574463 @default.
- W2900280130 hasConcept C161790260 @default.
- W2900280130 hasConcept C178790620 @default.
- W2900280130 hasConcept C184651966 @default.
- W2900280130 hasConcept C185592680 @default.
- W2900280130 hasConcept C197336794 @default.
- W2900280130 hasConcept C202751555 @default.
- W2900280130 hasConcept C21951064 @default.
- W2900280130 hasConcept C2777164566 @default.
- W2900280130 hasConcept C33923547 @default.
- W2900280130 hasConcept C518104683 @default.
- W2900280130 hasConcept C521977710 @default.
- W2900280130 hasConcept C54355233 @default.
- W2900280130 hasConcept C55493867 @default.
- W2900280130 hasConcept C62520636 @default.
- W2900280130 hasConcept C86803240 @default.
- W2900280130 hasConcept C91881484 @default.
- W2900280130 hasConcept C96232424 @default.
- W2900280130 hasConceptScore W2900280130C109316439 @default.
- W2900280130 hasConceptScore W2900280130C115537861 @default.
- W2900280130 hasConceptScore W2900280130C121332964 @default.
- W2900280130 hasConceptScore W2900280130C121608353 @default.
- W2900280130 hasConceptScore W2900280130C12554922 @default.
- W2900280130 hasConceptScore W2900280130C134306372 @default.
- W2900280130 hasConceptScore W2900280130C147789679 @default.
- W2900280130 hasConceptScore W2900280130C155574463 @default.
- W2900280130 hasConceptScore W2900280130C161790260 @default.
- W2900280130 hasConceptScore W2900280130C178790620 @default.
- W2900280130 hasConceptScore W2900280130C184651966 @default.
- W2900280130 hasConceptScore W2900280130C185592680 @default.
- W2900280130 hasConceptScore W2900280130C197336794 @default.
- W2900280130 hasConceptScore W2900280130C202751555 @default.
- W2900280130 hasConceptScore W2900280130C21951064 @default.
- W2900280130 hasConceptScore W2900280130C2777164566 @default.
- W2900280130 hasConceptScore W2900280130C33923547 @default.
- W2900280130 hasConceptScore W2900280130C518104683 @default.
- W2900280130 hasConceptScore W2900280130C521977710 @default.
- W2900280130 hasConceptScore W2900280130C54355233 @default.
- W2900280130 hasConceptScore W2900280130C55493867 @default.
- W2900280130 hasConceptScore W2900280130C62520636 @default.
- W2900280130 hasConceptScore W2900280130C86803240 @default.
- W2900280130 hasConceptScore W2900280130C91881484 @default.