Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900325739> ?p ?o ?g. }
- W2900325739 abstract "Myocardial infarction (MI) is the most prevalent cause of cardiovascular death. A possible way of preventing MI maybe by dietary supplements. The present study was thus designed to ascertain the cardio-protective effect of a formulated curcumin and nisin based poly lactic acid nanoparticle (CurNisNp) on isoproterenol (ISO) induced MI in guinea pigs. Animals were pretreated for 7 days as follows; Groups A and B animals were given 0.5 mL/kg of normal saline, group C metoprolol (2 mg/kg), groups D and E CurNisNp 10 and 21 mg/kg respectively (n = 5). MI was induced on the 7th day in groups B-E animals. On the 9th day electrocardiogram (ECG) was recorded, blood samples and tissue biopsies were collected for analyses. Toxicity studies on CurNisNp were carried out. MI induction caused atrial fibrillation which was prevented by pretreatment of metoprolol or CurNisNp. MI induction was also associated with increased expressions of cardiac troponin I (CTnI) and kidney injury molecule-1 (KIM-1) which were significantly reduced in guinea pig's pretreated with metoprolol or CurNisNp (P < 0.05). The LC50 of CurNisNp was 3258.2 μg/mL. This study demonstrated that the formulated curcumin-nisin based nanoparticle confers a significant level of cardio-protection in the guinea pig and is nontoxic." @default.
- W2900325739 created "2018-11-16" @default.
- W2900325739 creator A5009485766 @default.
- W2900325739 creator A5017250336 @default.
- W2900325739 creator A5018592288 @default.
- W2900325739 creator A5043078523 @default.
- W2900325739 creator A5043404389 @default.
- W2900325739 creator A5069489792 @default.
- W2900325739 creator A5069575555 @default.
- W2900325739 creator A5072712869 @default.
- W2900325739 date "2018-11-09" @default.
- W2900325739 modified "2023-10-08" @default.
- W2900325739 title "Cardioprotective Effects of Curcumin-Nisin Based Poly Lactic Acid Nanoparticle on Myocardial Infarction in Guinea Pigs" @default.
- W2900325739 cites W1217743210 @default.
- W2900325739 cites W1501685573 @default.
- W2900325739 cites W1506043065 @default.
- W2900325739 cites W1523119366 @default.
- W2900325739 cites W1553130581 @default.
- W2900325739 cites W1581414347 @default.
- W2900325739 cites W1750690213 @default.
- W2900325739 cites W1965579148 @default.
- W2900325739 cites W1965940007 @default.
- W2900325739 cites W1973729956 @default.
- W2900325739 cites W1974382336 @default.
- W2900325739 cites W1975932722 @default.
- W2900325739 cites W1976942216 @default.
- W2900325739 cites W1987739207 @default.
- W2900325739 cites W1993823264 @default.
- W2900325739 cites W2000300697 @default.
- W2900325739 cites W2000690385 @default.
- W2900325739 cites W2003930455 @default.
- W2900325739 cites W2006370393 @default.
- W2900325739 cites W2013446060 @default.
- W2900325739 cites W2021532865 @default.
- W2900325739 cites W2022981155 @default.
- W2900325739 cites W2037291605 @default.
- W2900325739 cites W2045421375 @default.
- W2900325739 cites W2046703464 @default.
- W2900325739 cites W2049205404 @default.
- W2900325739 cites W2050773334 @default.
- W2900325739 cites W2061689246 @default.
- W2900325739 cites W2066685510 @default.
- W2900325739 cites W2073092594 @default.
- W2900325739 cites W2075382404 @default.
- W2900325739 cites W2085539242 @default.
- W2900325739 cites W2087293880 @default.
- W2900325739 cites W2089185946 @default.
- W2900325739 cites W2095984133 @default.
- W2900325739 cites W2105868148 @default.
- W2900325739 cites W2116561323 @default.
- W2900325739 cites W2130814871 @default.
- W2900325739 cites W2131991255 @default.
- W2900325739 cites W2133784501 @default.
- W2900325739 cites W2134672309 @default.
- W2900325739 cites W2135070269 @default.
- W2900325739 cites W2141515673 @default.
- W2900325739 cites W2142693924 @default.
- W2900325739 cites W2145407418 @default.
- W2900325739 cites W2159900974 @default.
- W2900325739 cites W2160856601 @default.
- W2900325739 cites W2162734991 @default.
- W2900325739 cites W2167639932 @default.
- W2900325739 cites W2170822039 @default.
- W2900325739 cites W2172018609 @default.
- W2900325739 cites W2254978733 @default.
- W2900325739 cites W2338638760 @default.
- W2900325739 cites W2417347490 @default.
- W2900325739 cites W2462343910 @default.
- W2900325739 cites W2717120224 @default.
- W2900325739 cites W2746277913 @default.
- W2900325739 cites W2761934905 @default.
- W2900325739 cites W2766252262 @default.
- W2900325739 cites W2766906926 @default.
- W2900325739 cites W54604328 @default.
- W2900325739 doi "https://doi.org/10.1038/s41598-018-35145-5" @default.
- W2900325739 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6226538" @default.
- W2900325739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30413767" @default.
- W2900325739 hasPublicationYear "2018" @default.
- W2900325739 type Work @default.
- W2900325739 sameAs 2900325739 @default.
- W2900325739 citedByCount "40" @default.
- W2900325739 countsByYear W29003257392019 @default.
- W2900325739 countsByYear W29003257392020 @default.
- W2900325739 countsByYear W29003257392021 @default.
- W2900325739 countsByYear W29003257392022 @default.
- W2900325739 countsByYear W29003257392023 @default.
- W2900325739 crossrefType "journal-article" @default.
- W2900325739 hasAuthorship W2900325739A5009485766 @default.
- W2900325739 hasAuthorship W2900325739A5017250336 @default.
- W2900325739 hasAuthorship W2900325739A5018592288 @default.
- W2900325739 hasAuthorship W2900325739A5043078523 @default.
- W2900325739 hasAuthorship W2900325739A5043404389 @default.
- W2900325739 hasAuthorship W2900325739A5069489792 @default.
- W2900325739 hasAuthorship W2900325739A5069575555 @default.
- W2900325739 hasAuthorship W2900325739A5072712869 @default.
- W2900325739 hasBestOaLocation W29003257391 @default.
- W2900325739 hasConcept C115725540 @default.
- W2900325739 hasConcept C126322002 @default.
- W2900325739 hasConcept C185592680 @default.
- W2900325739 hasConcept C2775920511 @default.