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• W2900342494 abstract "The present study aims to discover novel serum biomarkers of early-onset myocardial infarction (MI) using proteomic analysis.In the first stage, the iTRAQ-coupled LC-MS/MS technique is utilized to investigate protein profiles of patients with early-onset MI. In the second stage, these candidate proteins are validated using ELISA.A total of 538 proteins are quantified, with pregnancy zone protein (PZP), leucine-rich α-2-glycoprotein (LRG) and Apolipoprotein C-I (Apo C-I) being upregulated and Apolipoprotein A-I (Apo A-I) and Apolipoprotein A-IV (Apo A-IV) downregulated in early-onset MI patients. Results from the validation stage demonstrate that the serum concentrations of PZP and LRG are significantly increased in the early-onset MI group. The correlation between the concentrations of C-reactive protein (CRP) and the two candidate biomarkers is positive. Area under the curve values used to diagnose early-onset MI for LRG and PZP are 0.939 and 0.874, respectively.Five differential serum proteins are identified in early-onset MI using proteomic analysis. Lipoprotein-related biomarkers further demonstrate the close relationship between lipid metabolism and the disease. Inflammation-associated LRG and PZP may be novel biomarkers of the disease. In addition, changes in these proteins may partly reveal the possible mechanisms in the pathogenesis and pathophysiology of early-onset MI." @default.
• W2900342494 created "2018-11-16" @default.
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• W2900342494 date "2018-11-28" @default.
• W2900342494 modified "2023-10-14" @default.
• W2900342494 title "Screening and Identification of Pregnancy Zone Protein and Leucine‐Rich Alpha‐2‐Glycoprotein as Potential Serum Biomarkers for Early‐Onset Myocardial Infarction using Protein Profile Analysis" @default.
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• W2900342494 doi "https://doi.org/10.1002/prca.201800079" @default.
• W2900342494 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30411527" @default.
• W2900342494 hasPublicationYear "2018" @default.
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